PPAN Inhibitors
PPAN, also known as Peter Pan, has roles integral to various phases of cellular growth, including larval growth, mitotic growth, oogenesis progression, and maturation of specific imaginal tissues. PPAN inhibitors can influence these pathways, either directly or indirectly. For instance, agents such as paclitaxel and colchicine can stabilize or disrupt microtubules, respectively. This can impact cell division, an essential component of mitotic growth. CDK inhibitors like Olomoucine II and Roscovitine are known to affect cell cycle progression, given that CDKs are crucial to different phases of the cell cycle.
PPAN's role in growth indicates that any perturbation in the cell cycle might influence its functions. Aurora kinase and Plk1 inhibitors, such as ZM 447439 and BI 2536 respectively, target proteins vital for mitotic progression. The interconnectedness of cell cycle proteins and the described functions of PPAN mean that agents affecting these proteins can also impact PPAN's functions. In essence, the selected inhibitors either play a direct role in pathways where PPAN is a component or can indirectly influence processes where PPAN is fundamental.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Binds to tubulin and stabilizes microtubules, affecting cell division which can indirectly influence PPAN functions related to mitotic growth. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Inhibits CDKs which are pivotal in cell cycle, potentially affecting PPAN-related cell growth functions. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Disrupts microtubules, affecting mitotic spindle formation and cell division which are processes linked to PPAN functions. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
CDK inhibitor that can hinder cell cycle progression related to PPAN functions. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds tubulin, disrupting microtubule polymerization affecting cell division processes associated with PPAN. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Affects kinesin proteins involved in mitosis, potentially influencing PPAN's role in cell growth. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Dihydrofolate reductase inhibitor that affects DNA synthesis. This can indirectly impact PPAN functions if it plays a role in DNA replication. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Inhibits ribonucleotide reductase, affecting DNA synthesis, potentially impacting PPAN-related processes. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
Aurora kinase inhibitor that affects mitosis, potentially influencing processes that PPAN is involved in. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
Plk1 inhibitor that plays a role in cell cycle regulation and can influence PPAN's mitotic growth-related functions. | ||||||