PP2Cζ Activators
PP2Cζ activatorsare chemicals that have the potential to indirectly enhance the activity of Protein phosphatase 1J (PP2Cζ) through different mechanisms affecting cellular signaling and enzyme regulation. These chemicals can lead to increased PP2Cζ activity by altering the balance of phosphorylation within the cell. For instance, forskolin raises intracellular cAMP levels, which could alter PP2Cζ activity as part of the cAMP-dependent signaling pathways. Similarly, inhibitors of other protein phosphatases such as okadaic acid, calyculin A, sodium fluoride, cantharidin, and endothall can lead to a compensatory increase in PP2Cζ activity to maintain overall phosphatase function within the cell. The involvement of these compounds in such compensatory mechanisms showcases the interconnectivity of cellular signaling networks, where altering one component can lead to adjustments in the activities of related enzymes.
Furthermore, essential cofactors like zinc and magnesium are required for optimal PP2Cζ function, and their supplementation can directly enhance the enzyme's catalytic activity. Compounds such as caffeine and hydrogen peroxide might affect PP2Cζ indirectly by triggering cellular stress responses that alter enzyme regulation and signaling pathway dynamics. Lastly, nitric oxide donors ((±)-S-Nitroso-N-acetylpenicillamine) and lithium chloride can modulate various cellular pathways, potentially leading to changes in the need for PP2Cζ activity as cells adjust to the modified signaling landscapes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator, increasing cAMP levels which can modulate signaling pathways, potentially resulting in altered phosphatase activity of PP2Cζ. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Specific inhibitor of other phosphatases (PP1, PP2A), which can cause a compensatory increase in PP2Cζ activity to maintain phosphatase function. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Inhibitor of PP1 and PP2A, similar to okadaic acid, potentially leading to compensatory upregulation of PP2Cζ activity. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Inhibitor of serine/threonine phosphatases which may lead to compensatory mechanisms involving PP2Cζ. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Inhibits PP2A and can lead to compensatory activation of PP2Cζ. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $48.00 $199.00 | 1 | |
Another PP2A inhibitor that can indirectly upregulate PP2Cζ activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
As a cofactor, zinc can enhance the activity of PP2C family enzymes, including PP2Cζ. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium acts as a cofactor necessary for PP2Cζ activity, and its presence is crucial for enzyme function. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Antagonist of adenosine receptors that may alter cellular energy states and indirectly affect PP2Cζ activity as part of cellular stress responses. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Induces oxidative stress, potentially modifying PP2Cζ activity as part of the cell’s response to this stress. | ||||||