PP2Cζ Inhibitors
PP2Cζ inhibitors encompass a diverse array of compounds tailored to indirectly modulate the functions of PP2Cζ, specifically its involvement in stress-activated protein kinase pathways. The kinase inhibitors play a pivotal role within this class, given the intricate network of kinases that interplay with PP2Cζ. For instance, Staurosporine, a potent inhibitor, targets a broad spectrum of kinases, indirectly modulating the PP2Cζ phosphatase activity. Compounds such as SB203580, SP600125, and PD98059 are strategically aimed at key kinases like p38 MAPK, JNK, and MEK, respectively. Inhibiting these kinases has cascading effects on the stress-activated protein kinase pathways, potentially influencing the actions of PP2Cζ within these routes.
The PI3K/AKT pathway, which holds significant cross-talk with the stress-activated protein kinase pathways, has also emerged as a crucial axis for PP2Cζ regulation. LY294002 and Wortmannin, both PI3K inhibitors, seek to temper this interplay, providing another layer of indirect regulation for PP2Cζ. On a similar note, Rapamycin and PP242 target mTOR, underscoring the multifaceted approach to modulate the complex interconnectivity of pathways that incorporate PP2Cζ's functionality. The inclusion of compounds like BAY 11-7082 further broadens the scope of PP2Cζ regulation by targeting NF-κB activation, another pathway that potentially intersects with PP2Cζ's sphere of influence.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A broad-spectrum kinase inhibitor. By inhibiting multiple kinases that interact with the stress-activated protein kinase pathways, it can indirectly influence PP2Cζ's phosphatase activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAPK, which is a part of the stress-activated protein kinase pathways. Since PP2Cζ plays a role in these pathways, inhibiting p38 MAPK can indirectly modulate the activity of PP2Cζ. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, another kinase within the stress-activated protein kinase pathways. By targeting JNK, it can indirectly affect PP2Cζ's functionality within this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits MEK, a kinase upstream of the MAPK/ERK pathway. By influencing the MAPK/ERK pathway, PD98059 can indirectly modulate the downstream functions in which PP2Cζ might be involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor. Since the PI3K/AKT pathway interacts with stress-activated protein kinase pathways, inhibiting PI3K can have indirect effects on PP2Cζ's role in these pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, which is interconnected with the stress-activated protein kinase pathways. By inhibiting mTOR, it can indirectly modulate PP2Cζ's activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor. By altering the PI3K/AKT pathway, it can indirectly influence PP2Cζ's functions or interactions in interconnected pathways. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
Inhibits mTORC1 and mTORC2, which have roles in signaling cascades interacting with stress-activated protein kinase pathways. This can indirectly affect PP2Cζ's functionality. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibits NF-κB activation. Given that NF-κB pathways can intersect with stress-activated protein kinase pathways, inhibiting NF-κB activation can have secondary effects on PP2Cζ's activity. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $208.00 $270.00 | 29 | |
Targets AKT, which is a part of the PI3K/AKT pathway. As this pathway can interact with stress-activated protein kinase pathways, inhibiting AKT can indirectly modulate PP2Cζ's role. | ||||||