PP2B Inhibitors

PP2B inhibitors, also known as protein phosphatase 2B inhibitors, belong to a class of small molecules that exert their biological effects by specifically targeting and inhibiting the activity of a cellular enzyme called protein phosphatase 2B (PP2B). PP2B, also known as calcineurin, is a critical enzyme involved in the regulation of intracellular calcium levels and cellular signaling pathways. It plays a pivotal role in numerous cellular processes, including cell growth, gene expression, and immune response. PP2B is particularly important in the context of immune cell activation and the immune response.

The mechanism of action of PP2B inhibitors involves their ability to bind to the active site of the PP2B enzyme, preventing it from dephosphorylating its substrates. This inhibition results in the dysregulation of downstream signaling pathways and ultimately affects cellular functions. Researchers have utilized PP2B inhibitors as valuable tools in basic research to dissect the intricate signaling pathways that underlie various physiological processes. By selectively inhibiting PP2B, scientists can investigate the role of this enzyme in specific cellular contexts and gain insights into its function in health and disease. Overall, PP2B inhibitors represent a class of compounds that have contributed significantly to our understanding of cellular signaling and have the potential for various applications.