Fenvalerate (CAS 51630-58-1)

4.0(1)

Application: Fenvalerate is a potent inhibitor of calcineurin with suggested activity at GABA receptors and other neuronal activity

CAS Number: 51630-58-1

Purity: ≥98%

Molecular Weight: 419.9

Molecular Formula: C₂₅H₂₂ClNO₃

Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Fenvalerate is a synthetic compound that modulates sodium channels in the nerve cell membrane and also acts as a potent PP2B-Aα (calcineurin) inhibitor IC₅₀~20 nM; however, serious doubts have been raised about the efficacy of this inhibitor. This compound has also been shown to have possible GABA receptor activity, yielding anxiogenic effects in rats.

References

1. Böcker, F. 1977. Med Welt. 28: 1678-1681. PMID: 927133
2. Enan, E. and Matsumura, F. 1992. Biochem. Pharmacol. 43: 1777-1784. PMID: 1315545
3. Narahashi, T. 1992. Trends Pharmacol. Sci. 13: 236-241. PMID: 1321523
4. De Souza Spinosa, H., et al. 1999. Physiol. Behav. 67: 611-615. PMID: 10549901

Appearance :

Powder

Physical State :

Solid

Solubility :

Soluble in 100% ethanol (>25 mg/ml), water (0.001 g/l) at 20 °C, and DMSO.

Storage :

Store at 4° C

Melting Point :

83.72° C (Predicted)

Boiling Point :

~538.9° C at 760 mmHg (Predicted)

Density :

~1.2 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.59

IC50 :

calcineurin (protein phosphatase 2B): IC₅₀ = ~20 nM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

CY1576350

Transport :

UN 2811, Class 6.1, Packing group III

PubChem CID :

3347

Merck Index :

14: 4010

MDL Number :

MFCD00055324

EC Number :

257-326-3

Beilstein Registry :

2025982

SMILES :

CC(C)C(C1=CC=C(C=C1)Cl)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3

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Certificate of Analysis

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Fenvalerate (CAS 51630-58-1) Product Citations

See how others have used Fenvalerate (CAS 51630-58-1). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 18927309 de Bono, JS. et al. 2008. Clin. Cancer Res. 14: 6663-6673.

PMID: # 16452087 Trinidad JC, et al. 2006. Mol Cell Proteomics. 5(5): 914-922.

1995. Pesticide Biochemistry and Physiology. 51: 214-219.

Citations 1 to 3 of 3 total

What is the appearance of the compound?

Asked by: two2igm05

Thank you for your question. The compound, sc-24014, is provided as a white to off-white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.

Answered by: Tech Service 8

Date published: 2017-01-20

Rated 4 out of 5 by SH from de Bono de Bono, et. al. (PubMed ID 158927309) included fenvalerate in their tumor extract at a concentration of 0.1%. -SCBT Publication Review

Date published: 2015-01-13

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