Fenvalerate is a synthetic compound that modulates sodium channels in the nerve cell membrane and also acts as a potent PP2B-Aα (calcineurin) inhibitor IC50~20 nM; however, serious doubts have been raised about the efficacy of this inhibitor. This compound has also been shown to have possible GABA receptor activity, yielding anxiogenic effects in rats.
1. Böcker, F. 1977. Med Welt. 28: 1678-1681. PMID: 927133 2. Enan, E. and Matsumura, F. 1992. Biochem. Pharmacol. 43: 1777-1784. PMID: 1315545 3. Narahashi, T. 1992. Trends Pharmacol. Sci. 13: 236-241. PMID: 1321523 4. De Souza Spinosa, H., et al. 1999. Physiol. Behav. 67: 611-615. PMID: 10549901
Soluble in 100% ethanol (>25 mg/ml), water (0.001 g/l) at 20 °C, and DMSO.
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