Fenvalerate CAS: 51630-58-1
MF: C25H22ClNO3
MW: 419.9
A potent inhibitor of calcineurin with suggested activity at GABA receptors and other neuronal activity.

Fenvalerate (CAS 51630-58-1)

Fenvalerate | CAS 51630-58-1 is rated 4.0 out of 5 by 1.
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Application: Fenvalerate is a potent inhibitor of calcineurin with suggested activity at GABA receptors and other neuronal activity
CAS Number: 51630-58-1
Purity: ≥98%
Molecular Weight: 419.9
Molecular Formula: C25H22ClNO3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Fenvalerate is a synthetic compound that modulates sodium channels in the nerve cell membrane and also acts as a potent PP2B-Aα (calcineurin) inhibitor IC50~20 nM; however, serious doubts have been raised about the efficacy of this inhibitor. This compound has also been shown to have possible GABA receptor activity, yielding anxiogenic effects in rats.


References

1. Böcker, F. 1977. Med Welt. 28: 1678-1681. PMID: 927133
2. Enan, E. and Matsumura, F. 1992. Biochem. Pharmacol. 43: 1777-1784. PMID: 1315545
3. Narahashi, T. 1992. Trends Pharmacol. Sci. 13: 236-241. PMID: 1321523
4. De Souza Spinosa, H., et al. 1999. Physiol. Behav. 67: 611-615. PMID: 10549901

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in 100% ethanol (>25 mg/ml), water (0.001 g/l) at 20 °C, and DMSO.
Storage :
Store at 4° C
Melting Point :
83.72° C (Predicted)
Boiling Point :
~538.9° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59
IC50 :
calcineurin (protein phosphatase 2B): IC50 = ~20 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CY1576350
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
3347
Merck Index :
14: 4010
MDL Number :
MFCD00055324
EC Number :
257-326-3
Beilstein Registry :
2025982
SMILES :
CC(C)C(C1=CC=C(C=C1)Cl)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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Fenvalerate (CAS 51630-58-1)  Product Citations

See how others have used Fenvalerate (CAS 51630-58-1). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 18927309  de Bono, JS. et al. 2008. Clin. Cancer Res. 14: 6663-6673.

PMID: # 16452087  Trinidad JC, et al. 2006. Mol Cell Proteomics. 5(5): 914-922.

1995. Pesticide Biochemistry and Physiology. 51: 214-219.

Citations 1 to 3 of 3 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-24014, is provided as a white to off-white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-20
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Rated 4 out of 5 by from de Bono de Bono, et. al. (PubMed ID 158927309) included fenvalerate in their tumor extract at a concentration of 0.1%. -SCBT Publication Review
Date published: 2015-01-13
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