PP2B-Aα Inhibitors
PP2B-Aα Inhibitors comprise a diverse range of compounds that indirectly influence the activity of PP2B-Aα, primarily through modulation of calcium signaling and interactions with calmodulin, which are crucial for the activation of calcineurin. These inhibitors do not directly target PP2B-Aα; instead, they exert their effects on related cellular processes and signaling pathways. Compounds like Cyclosporine A and FK506 (Tacrolimus) are classic examples of indirect inhibitors of PP2B-Aα. They function by forming complexes with immunophilins (cyclophilin and FKBP12, respectively), which then inhibit calcineurin. This inhibition effectively blocks the phosphatase activity of PP2B-Aα. Similarly, Trifluoperazine and W-7 Hydrochloride, as calmodulin antagonists, disrupt the activation mechanism of calcineurin by calmodulin, thereby indirectly inhibiting PP2B-Aα.
Additionally, calcium channel blockers such as Verapamil, Nifedipine, Diltiazem, and Amlodipine indirectly inhibit PP2B-Aα by reducing calcium influx. Calcium is a critical activator of calcineurin, and lowering intracellular calcium levels can consequently inhibit calcineurin-mediated dephosphorylation activities of PP2B-Aα. Phenylephrine, by modulating calcium signaling through alpha-1 adrenergic receptors, and Lithium Chloride, through its effects on multiple signaling pathways, can also indirectly influence PP2B-Aα activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporine A forms a complex with cyclophilin and inhibits calcineurin by preventing its interaction with calmodulin, thereby indirectly inhibiting PP2B-Aα activity. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 binds to FKBP12, forming a complex that inhibits calcineurin and indirectly inhibits PP2B-Aα by blocking its phosphatase activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
While primarily an mTOR inhibitor, Rapamycin can indirectly affect PP2B-Aα by altering downstream pathways that interact with calcineurin signaling. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil, a calcium channel blocker, can indirectly inhibit PP2B-Aα by reducing calcium influx, essential for calcineurin activation. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine, another calcium channel blocker, decreases intracellular calcium levels, potentially inhibiting PP2B-Aα activation. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem reduces calcium availability by blocking calcium channels, potentially inhibiting PP2B-Aα activity indirectly. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
Amlodipine, a calcium channel antagonist, can indirectly inhibit PP2B-Aα by lowering intracellular calcium levels. | ||||||
L-phenylephrine | 59-42-7 | sc-295315 sc-295315A | 5 g 25 g | $181.00 $492.00 | 2 | |
Phenylephrine, an alpha-1 adrenergic receptor agonist, can modulate calcium signaling, potentially indirectly inhibiting PP2B-Aα. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can modulate several signaling pathways, potentially affecting those that intersect with PP2B-Aα activity. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 Hydrochloride, another calmodulin antagonist, can indirectly inhibit PP2B-Aα by interfering with calmodulin's regulatory role. | ||||||