POU3F4 Activators
POU3F4 Activators are a class of small molecules that have garnered significant attention in the field of molecular biology and genetic research due to their unique ability to modulate the activity of the POU3F4 transcription factor. POU3F4, also known as BRN4, is a member of the POU-domain transcription factor family, and it plays a pivotal role in the regulation of gene expression during embryonic development and tissue differentiation. POU3F4 is primarily expressed in the inner ear, where it is crucial for the development and maintenance of auditory and vestibular sensory hair cells, making it a key player in hearing and balance. The activation of POU3F4 by specific small molecules has the potential to influence the expression of downstream target genes involved in inner ear development and function.
POU3F4 Activators function by binding to specific regions of the POU3F4 protein, thereby enhancing its DNA-binding affinity and transcriptional activity. This interaction leads to increased expression of genes that are under the control of POU3F4, which in turn can impact inner ear development and sensory cell differentiation. While the precise mechanisms of action of POU3F4 Activators may vary, they share a common goal of amplifying the regulatory function of POU3F4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Modulates the Wnt signaling pathway, indirectly activating POU3F4 by regulating downstream factors in the Wnt pathway. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibits the TGF-β receptor, indirectly activating POU3F4 by modulating the TGF-β signaling pathway, which may have downstream effects on POU3F4 transcription. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Functions as a PI3K inhibitor, indirectly activating POU3F4 by modulating the PI3K/Akt pathway, which plays a role in activating gene regulation and may activate POU3F4 expression. | ||||||
AG-490 | 133550-30-8 | sc-202046C sc-202046A sc-202046B sc-202046 | 5 mg 50 mg 25 mg 10 mg | $84.00 $329.00 $223.00 $87.00 | 35 | |
Inhibits JAK/STAT signaling, indirectly activating POU3F4 by modulating the JAK/STAT pathway, which is involved in activating transcriptional regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Serves as an HDAC inhibitor, indirectly activating POU3F4 by modifying histone acetylation, which can activate chromatin structure and gene expression, including POU3F4. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Acts as a DNA methylation inhibitor, indirectly activating POU3F4 by modifying DNA methylation patterns that can activate gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Acts as an epigenetic modulator, indirectly activating POU3F4 by potentially affecting histone methylation or acetylation, which can activate gene expression. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
Functions as a PPAR-γ agonist, indirectly activating POU3F4 through PPAR-γ activation, which may have downstream effects on transcription factors like POU3F4. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Acts as a proteasome inhibitor, indirectly activating POU3F4 by stabilizing proteins that interact with POU3F4, potentially activating its function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Serves as a broad-spectrum protein kinase activator, indirectly activating POU3F4 by inhibiting various protein kinases that can activate phosphorylation and regulate transcription factors like POU3F4. | ||||||