Pol2 Activators
Pol2 Activators refers to compounds that are capable of increasing the activity of RNA polymerase II (Pol II), which is a key enzyme in the eukaryotic transcription machinery responsible for transcribing DNA into messenger RNA (mRNA). Pol II is a complex enzyme, and its activity can be influenced by a variety of factors, including the presence of specific activator proteins and small molecules. These interactions involve direct binding to the polymerase itself, binding to regulatory proteins that modulate Pol II, or altering the structure of the chromatin to make it more accessible to the transcription machinery.
Chemically, Pol2 Activators represent a structurally diverse set of molecules. They include various small molecules that can permeate the cell nucleus and interact directly with the Pol II enzyme or its co-factors. The structures of these activators are specifically designed to fit into the binding sites on Pol II or to modulate its interactions with other proteins and DNA. The activators mimic the action of natural transcription factors or other regulatory molecules, or they act by stabilizing the transcription initiation complex.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea causes replication stress by inhibiting ribonucleotide reductase, potentially increasing the need for DNA repair enzymes like Pol ε. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin introduces intrastrand DNA crosslinks, which can stall replication forks and may upregulate DNA repair proteins such as Pol ε. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
MMS alkylates DNA, leading to errors during replication and potentially enhancing the expression of high-fidelity polymerases like Pol ε. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is a specific inhibitor of DNA polymerases, including Pol ε, causing replication stress which may induce compensatory increases in Pol ε levels. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide causes DNA breaks by inhibiting topoisomerase II, possibly triggering a cellular response that includes upregulation of Pol ε. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, leading to single-strand breaks that may stimulate the expression of DNA repair enzymes like Pol ε. | ||||||
Atrazine | 1912-24-9 | sc-210846 | 5 g | $165.00 | 1 | |
Atrazine is known to induce oxidative stress, which can indirectly lead to DNA damage and potentially enhance Pol ε expression as a response. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic compounds generate oxidative stress and can cause DNA damage, potentially increasing the expression of DNA repair enzymes, including Pol ε. | ||||||
Acrylamide Solution, 40% | 79-06-1 | sc-3721 | 1 L | $100.00 | ||
Acrylamide can form DNA adducts and cause genetic damage, which may result in the upregulation of DNA polymerases like Pol ε for repair. | ||||||
Benzene | 71-43-2 | sc-239290 | 1 L | $79.00 | ||
Benzene metabolites induce DNA damage, which might activate cellular pathways to increase the levels of DNA repair proteins such as Pol ε. | ||||||