Pol2 Inhibitors
Pol2 inhibitors are a class of chemicals that can inhibit the function of the Pol2 protein, also known as RNA polymerase II. Pol2 is a key enzyme involved in transcription, responsible for synthesizing messenger RNA (mRNA) from DNA templates. The inhibitors of Pol2 can act through various mechanisms to disrupt its function. α-Amanitin, a cyclic peptide toxin found in certain mushrooms, specifically targetsand binds to RNA polymerase II, preventing its elongation and leading to the inhibition of transcription. Actinomycin D, an antibiotic, intercalates into DNA and prevents the formation of the transcription initiation complex, blocking the binding of Pol2 to the DNA template. Rifampicin, primarily used against bacterial Pol2, can also inhibit eukaryotic Pol2 by interfering with the initiation and elongation phases of transcription. Triptolide, a natural compound, binds to the initiation complex and prevents the release of Pol2 from the promoter, inhibiting transcription.
DRB, a synthetic compound, targets the C-terminal domain (CTD) of Pol2 and disrupts the assembly of the transcription initiation complex by interfering with CTD phosphorylation. Flavopiridol, another synthetic compound, inhibits Pol2 by targeting cyclin-dependent kinases (CDKs) involved in transcription regulation, preventing Pol2 phosphorylation and inhibiting transcription. Mycophenolic acid, an immunosuppressive compound, indirectly inhibits Pol2 by targeting inosine monophosphate dehydrogenase (IMPDH), depleting cellular guanine nucleotide pools necessary for Pol2 function. Fludarabine, an anticancer compound, interferes with DNA synthesis and repair processes, causing DNA damage and inhibiting Pol2-mediated transcription. Overall, Pol2 inhibitors encompass a range of chemicals that can target Pol2 or disrupt its function by interfering with transcription initiation, elongation, or other related cellular processes. These inhibitors provide valuable tools for studying the role of Pol2 in transcription.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin is a cyclic peptide toxin found in certain species of mushrooms. It can inhibit Pol2 by specifically targeting and binding to RNA polymerase II, preventing its elongation and leading to the inhibition of transcription. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D is an antibiotic that can inhibit Pol2 by intercalating into DNA and preventing the formation of the transcription initiation complex. This inhibition blocks the binding of Pol2 to the DNA template, thereby inhibiting transcription. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin is an antibiotic that can inhibit Pol2 by binding to the β-subunit of bacterial RNA polymerase. Although primarily used against bacterial Pol2, it can also have inhibitory effects on eukaryotic Pol2 by interfering with the initiation and elongation phases of transcription. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide is a natural compound found in the Chinese herb Tripterygium wilfordii. It can inhibit Pol2 by binding to the initiation complex and preventing the release of RNA polymerase II from the promoter, leading to the inhibition of transcription. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB is a synthetic compound that can inhibit Pol2 by targeting the C-terminal domain (CTD) of RNA polymerase II. It interferes with the phosphorylation of the CTD, disrupting the assembly of the transcription initiation complex and inhibiting transcription. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol is a synthetic compound that can inhibit Pol2 by targeting the cyclin-dependent kinases (CDKs) involved in transcription regulation. It blocks the activity of CDKs, preventing the phosphorylation of Pol2 and inhibiting transcription. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Mycophenolic acid is an immunosuppressive compound that can inhibit Pol2 by targeting the enzyme inosine monophosphate dehydrogenase (IMPDH), which is involved in the synthesis of guanine nucleotides. By depleting the cellular pool of guanine nucleotides, it can indirectly inhibit Pol2 and transcription. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $57.00 $200.00 | 15 | |
Fludarabine is an anticancer compound that can inhibit Pol2 by interfering with DNA synthesis and repair processes. It can cause DNA damage, leading to the inhibition of Pol2-mediated transcription. | ||||||