POGZ Activators
POGZ Activators comprise a selection of chemical compounds that indirectly enhance the functional activity of POGZ by modulating various signaling pathways and altering the chromatin landscape. Compounds such as Forskolin, 8-Br-cAMP, IBMX, and Rolipram upregulate intracellular cAMP levels, which can activate PKA, a kinase that may phosphorylate POGZ or associated proteins, thereby influencing POGZ's role in chromatin remodeling and gene expression regulation. This modulation is critical since POGZ is a chromatin-associated factor that influences genomic stability and transcription. Similarly, Epigallocatechin gallate (EGCG) and Trichostatin A (TSA) inhibit class I HDACs, resulting in a more open chromatin state that could enhance POGZ's ability to regulate gene expression. Sodium butyrate and SAHA (Vorinostat),also HDAC inhibitors, contribute to this effect by increasing acetylation levels of histones, facilitating POGZ's interaction with chromatin and enhancing its role in gene regulation.
Furthermore, the action of DNA methyltransferase inhibitors like 5-Azacytidine, Zebularine, and Resveratrol may complement the activity of POGZ by creating a chromatin environment that is less methylated, thus more transcriptionally active, which can potentiate the regulatory functions of POGZ in gene expression. On the other hand, S-Adenosylmethionine (SAM) as a methyl donor could indirectly affect POGZ function by contributing to the dynamic methylation landscape that POGZ may interact with during chromatin remodeling. The biochemical modulation of these pathways by the identified activators does not merely alter the expression levels of POGZ but rather enhances its functional activity by affecting the structural and regulatory context within which POGZ operates, highlighting the intricate relationship between chromatin state and POGZ-mediated regulation of genomic functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing levels of cyclic AMP (cAMP) which can enhance the activity of POGZ by activating PKA that may phosphorylate POGZ or associated proteins, influencing chromatin remodeling and gene expression regulation. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Br-cAMP acts as a cAMP analog, directly stimulating PKA. The activation of PKA can enhance POGZ function by potential phosphorylation or modulation of POGZ's interaction with other proteins involved in chromatin structure and function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which increases intracellular cAMP and cGMP by preventing their degradation. Elevated cAMP can lead to PKA activation, potentially enhancing the functional role of POGZ in chromatin regulation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cAMP levels and subsequent PKA activation, potentially enhancing POGZ-mediated gene expression regulation through phosphorylation of POGZ or its associated factors. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol that inhibits class I histone deacetylases (HDACs). POGZ, which has a role in chromatin remodeling, might see its function enhanced by the more open chromatin state due to HDAC inhibition. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is an inhibitor of histone deacetylases, leading to hyperacetylated chromatin, which may facilitate POGZ's role in chromatin remodeling and gene expression by providing a more accessible DNA structure. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, causing DNA demethylation. This can create a more permissive chromatin environment, potentially enhancing POGZ's ability to regulate gene expression. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAM serves as a methyl donor for DNA and histone methylation. Enhanced methylation can indirectly affect POGZ function by altering chromatin states and gene expression profiles that POGZ may interact with. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is an HDAC inhibitor, leading to a more relaxed chromatin state. This may enhance POGZ's role in chromatin remodeling and interaction with transcriptional machinery. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
Zebularine is a DNA methyltransferase inhibitor, which can lead to DNA demethylation and potentially enhance POGZ-mediated gene regulation by affecting chromatin structure. | ||||||