POEM Activators
POEM Activators represent a group of chemical compounds that specifically amplify the functional activity of POEM, a protein known to modulate extracellular matrix remodeling. These activators either directly or indirectly stimulate POEM activity through unique signaling pathways that POEM is directly engaged in. For instance, Acetylcholine, an activator of the cholinergic pathway, enhances POEM function by stimulating this pathway. Similarly, Bradykinin, acting on the bradykinin B2 receptor signaling pathway, can also potentiate POEM activity. Sphingosine 1-Phosphate and LPA are activators of the Rho GTPase pathway, which can augment POEM function by promoting this pathway's activity.
Furthermore, POEM activity is intimately linked with the cAMP-dependent pathway, and the activation of this pathway bycompounds such as Forskolin, Rolipram, and IBMX can enhance the function of POEM. These compounds either directly activate or inhibit enzymes involved in cAMP metabolism, fostering an environment conducive for POEM activation. In the same vein, neurotransmitters such as Histamine, Dopamine, and Serotonin, which act on their respective receptor pathways, can also boost POEM function. Lastly, lipid compounds including Prostaglandin E2 and Leukotriene B4, known for their roles in inflammation and immune response, can activate pathways that lead to enhanced functional activity of POEM.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine 1-Phosphate activates the Rho GTPase signaling pathway. As POEM is involved in extracellular matrix remodeling downstream of this pathway, activation of the Rho GTPase signaling pathway by Sphingosine 1-Phosphate can enhance the function of POEM. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA activates the Rho GTPase signaling pathway. As POEM is involved in extracellular matrix remodeling downstream of this pathway, activation of the Rho GTPase signaling pathway by LPA can enhance the function of POEM. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent activator of adenylate cyclase, thereby increasing the intracellular levels of cAMP. Given that POEM is involved in extracellular matrix remodeling downstream of the cAMP-dependent pathway, activation of this pathway by Forskolin can enhance the function of POEM. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), thereby increasing the intracellular levels of cAMP. Given that POEM is involved in extracellular matrix remodeling downstream of the cAMP-dependent pathway, inhibition of PDE4 by Rolipram can enhance the function of POEM. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases (PDEs), thereby increasing the intracellular levels of cAMP. Given that POEM is involved in extracellular matrix remodeling downstream of the cAMP-dependent pathway, inhibition of PDEs by IBMX can enhance the function of POEM. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine is a neurotransmitter that activates the H1-H4 receptors pathway. Since POEM is involved in extracellular matrix remodeling downstream of this pathway, activation of the histaminergic pathway by Histamine can enhance the function of POEM. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine is a neurotransmitter that activates the D1-D5 receptors pathway. As POEM is involved in extracellular matrix remodeling downstream of this pathway, activation of the dopaminergic pathway by Dopamine can enhance the function of POEM. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $118.00 $187.00 | 15 | |
Serotonin is a neurotransmitter that activates the 5-HT receptors pathway. As POEM is involved in extracellular matrix remodeling downstream of this pathway, activation of the serotonergic pathway by Serotonin can enhance the function of POEM. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 is a lipid compound that activates the prostaglandin E2 receptor EP1-EP4 pathway. As POEM is involved in extracellular matrix remodeling downstream of this pathway, activation of this pathway by Prostaglandin E2 can enhance the function of POEM. | ||||||
LTB4 (Leukotriene B4) | 71160-24-2 | sc-201043 | 50 µg | $374.00 | 4 | |
Leukotriene B4 is a lipid compound that activates the LTB4 receptor BLT1/BLT2 pathway. As POEM is involved in extracellular matrix remodeling downstream of this pathway, activation of this pathway by Leukotriene B4 can enhance the function of POEM. | ||||||