PMCA1 Activators
Plasma Membrane Calcium ATPase 1 (PMCA1) is a member of the calcium-transporting ATPase family, primarily responsible for actively transporting calcium ions out of the cell against their concentration gradient. This transport activity is crucial for maintaining proper calcium homeostasis within cells, as excessive intracellular calcium levels can lead to various cellular dysfunctions. PMCA1 activators are compounds that can enhance the function of PMCA1 in pumping calcium ions out of the cell, ultimately contributing to the regulation of intracellular calcium levels.
The mechanisms by which PMCA1 activators work can vary, but they generally target PMCA1 directly or indirectly to promote its calcium-pumping activity. These activators may interact with specific domains or regulatory sites on PMCA1, leading to conformational changes that increase its calcium-transporting efficiency. Alternatively, some activators may modulate the cellular environment in ways that support PMCA1 function, such as by optimizing ATP availability, maintaining suitable membrane fluidity, or oxidative damage. Understanding and studying PMCA1 activators are essential for unraveling the intricate regulatory mechanisms that govern cellular calcium homeostasis. Research in this area can shed light on potential strategies for maintaining calcium balance within cells under various physiological and pathological conditions
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a commonly used calcium ionophore. It is a natural product found in Streptomyces conglobatus. Ionomycin is highly selective for calcium ions and can carry calcium across cell membranes. Once inside the cell, it releases the calcium ions, causing an increase in intracellular calcium levels. This rise in calcium concentration can activate various calcium-dependent processes and signaling pathways. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Ouabain can inhibit Na+/K+-ATPase, leading to an increase in cytosolic Na+. This can trigger the Na+/Ca2+ exchanger to reverse, increasing intracellular Ca2+ and subsequently activating PMCA1 for calcium extrusion. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
12β-Hydroxydigitoxin, similar to ouabain, can inhibit Na+/K+-ATPase and increase intracellular Ca2+, indirectly enhancing PMCA1 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another well-known calcium ionophore. It is an antibiotic produced by Streptomyces chartreusensis. Like ionomycin, A23187 is highly selective for calcium ions and can transport them across cellular membranes. Researchers commonly use A23187 in experiments to manipulate intracellular calcium levels and study calcium-dependent processes. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $33.00 $83.00 | 5 | |
Nicardipine is an L-type calcium channel blocker. It can lead to an increase in intracellular Ca2+, necessitating PMCA1 activation for calcium extrusion. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil, another L-type calcium channel blocker, can increase intracellular Ca2+, indirectly enhancing PMCA1 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin can inhibit the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic Ca2+ and subsequently activating PMCA1. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine can induce Ca2+ release from intracellular stores, indirectly enhancing PMCA1 activity for calcium extrusion. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP can directly stimulate PMCA1, as it is an essential component for the pump's function. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $300.00 | ||
Calmodulin binds to PMCA1 in a Ca2+-dependent manner, enhancing its pump activity. | ||||||