PLP2 Activators
PLP2 Activators encompass a diverse range of chemical compounds that indirectly augment the functional activity of PLP2 through a variety of signaling pathways. Forskolin, by increasing intracellular cAMP levels, indirectly activates PLP2 by enabling PKA to phosphorylate proteins that affect PLP2's stability or activity within the cell membrane. Ionomycin and A23187 act as calcium ionophores, raising intracellular calcium levels, which may stimulate calcium-dependent kinases known to phosphorylate PLP2 or proteins closely associated with it, thus enhancing its activity. Phorbol 12-myristate 13-acetate (PMA) and Sphingosine-1-phosphate (S1P) activate PKC and S1P receptor pathways, respectively, both of which can lead to modifications of PLP2 that potentiate its activity in signaling. Epigallocatechin gallate (EGCG), by inhibiting certain kinases, could reduce inhibitory phosphorylation events that dampen PLP2 activity, leading to its functional activation. This is complemented by Wortmannin, a PI3K inhibitor that may shift signaling towards pathways that activate PLP2, and by FTY720, which mimics S1P and can activate similar signaling cascades.
Dibutyryl-cAMP (db-cAMP) and Isoproterenol both serve to enhance PLP2 function through the elevation of cAMP and subsequent PKA activation, which is known to phosphorylate targets that can include PLP2, thereby enhancing its activity. The MEK inhibitor U0126, while primarily known for reducing ERK phosphorylation, could indirectly upregulate PLP2 activity by lifting the inhibition exerted by negative feedback loops or by enhancing alternative signaling pathways that lead to PLP2 activation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate PLP2, enhancing its activity by promoting its proper folding or stabilization in the membrane. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. This increase can activate calcium-dependent kinases, which could then phosphorylate PLP2 or associated proteins, indirectly enhancing PLP2 functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which could phosphorylate PLP2 or influence its interaction with other membrane proteins, thereby potentially enhancing its functional activity within its specific signaling pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P interacts with its G-protein-coupled receptors to activate downstream kinase signaling pathways, which could lead to post-translational modifications of PLP2, potentially enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol that can inhibit various kinases, potentially reducing negative regulatory phosphorylation on PLP2 or other proteins within its pathway, resulting in an overall increase in PLP2 activity. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720, once phosphorylated, acts similarly to S1P and could bind to S1P receptors, potentially triggering signaling cascades that enhance the activity of PLP2 through its effects on cellular signaling. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA, which may lead to the phosphorylation and subsequent activation of PLP2 or proteins in its pathway that influence PLP2 activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels in cells, leading to PKA activation which could phosphorylate PLP2 and enhance its activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore which, similar to ionomycin, elevates intracellular calcium and could activate calcium-dependent signaling pathways that enhance PLP2 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that could similarly enhance PLP2's activity by altering upstream signaling pathways, leading to a compensatory increase in the pathways that activate PLP2. | ||||||