PIWIL4 Inhibitors
PIWIL4 is a member of the Argonaute protein family that interacts with piRNAs to form RNA-protein complexes essential for the silencing of retrotransposons and other genetic elements, especially in the germ line. The compounds mentioned are not direct inhibitors of PIWIL4 but rather act on various aspects of the cellular machinery that indirectly impact the function of PIWIL4. They include inhibitors of RNA polymerase that reduce piRNA levels, inhibitors of histone modification enzymes that can alter chromatin structure and thus affect piRNA gene expression, and other compounds that influence RNA processing and the cellular signaling pathways relevant to RNA silencing.
The chemical class of indirect PIWIL4 inhibitors encompasses a diverse set of molecules that target different stages of RNA metabolism and chromatin modification. By affecting these processes, the compounds could potentially disrupt the formation and function of PIWIL4-containing RNA-induced silencing complexes. These inhibitors could alter the epigenetic state of piRNA clusters, modulate the transcription of piRNA precursors, or interfere with the maturation and stability of piRNAs, all of which are crucial for the regulatory functions performed by PIWIL4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
A compound that intercalates into DNA and inhibits RNA polymerase, potentially affecting piRNA transcription and PIWIL4 function. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
A potent inhibitor of RNA polymerase II that could reduce the transcription of piRNA precursors, potentially impacting PIWIL4 activity. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A diterpene triepoxide that inhibits RNA polymerase I, II, and III, which may reduce piRNA precursor levels and affect PIWIL4. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $124.00 $502.00 | 13 | |
An inhibitor of histone acetyltransferases (HATs) that could alter chromatin structure and affect piRNA gene expression, hence PIWIL4 function. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
A histone methyltransferase inhibitor that could influence chromatin dynamics and potentially affect the expression of genes involved in PIWIL4 pathways. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
A diazepin-quinazolin-amine derivative that inhibits G9a and GLP histone methyltransferases, potentially affecting chromatin states and PIWIL4 activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog that incorporates into RNA and DNA and inhibits DNA methyltransferases, potentially affecting piRNA expression and PIWIL4 function. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor that might affect the transcription of piRNA clusters and impact PIWIL4’s role in gene silencing. | ||||||
Pyridostatin | 1085412-37-8 | sc-476422 | 10 mg | $350.00 | ||
A G-quadruplex stabilizer which could potentially interfere with the transcription of G-rich piRNA precursors, impacting PIWIL4 function. | ||||||
1,10-Phenanthroline | 66-71-7 | sc-255888 sc-255888A | 2.5 g 5 g | $23.00 $32.00 | ||
A metal ion chelator that can interfere with metal-dependent enzymes and potentially impact RNA processing factors involved with PIWIL4 activity. | ||||||