PITRM1 Inhibitors
PIP5KII inhibitors are a class of compounds that target phosphatidylinositol-5-phosphate 4-kinase type II (PIP5KII), an enzyme involved in the regulation of phosphatidylinositol signaling pathways. PIP5KII is responsible for the phosphorylation of phosphatidylinositol-5-phosphate (PI5P) to generate phosphatidylinositol-4,5-bisphosphate (PIP2), a critical lipid signaling molecule that plays a key role in various cellular processes such as membrane trafficking, cytoskeletal organization, and signal transduction. Inhibitors of PIP5KII function by blocking this enzymatic activity, which reduces the levels of PIP2, thereby affecting downstream signaling events that are regulated by PIP2-dependent proteins and pathways.
Researchers utilize PIP5KII inhibitors to investigate the role of PIP2 in cellular processes, particularly those related to the regulation of membrane dynamics and intracellular signaling. By inhibiting PIP5KII, these compounds provide a tool to study how alterations in PIP2 levels impact processes such as actin cytoskeleton remodeling, endocytosis, and vesicle trafficking. PIP5KII inhibitors are also valuable in understanding the role of phosphoinositide metabolism in cell signaling, as well as in exploring the broader phosphoinositide pathway network. Their use in research allows for deeper insights into how lipid kinases like PIP5KII contribute to fundamental cellular functions, and how disruptions in these pathways may lead to changes in cellular behavior, offering new perspectives on phosphoinositide-dependent cellular mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor can cause demethylation of the PITRM1 gene promoter, potentially leading to the downregulation of its transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can increase acetylation of histones near the PITRM1 gene, potentially reducing its transcriptional activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 can prevent the degradation of ubiquitinated proteins, leading to an accumulation that may trigger a cellular stress response, potentially decreasing PITRM1 expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
By intercalating into DNA, Actinomycin D can blunt transcription initiation and elongation, which could lead to a reduction in PITRM1 mRNA synthesis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide blocks the translocation step of protein synthesis on ribosomes, which could create feedback loops that downregulate PITRM1 gene expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
This mTOR inhibitor can lead to a decrease in cap-dependent translation, potentially causing a decrease in the synthesis of proteins including those involved in PITRM1 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid binds to retinoic acid receptors which then bind to retinoic acid response elements in DNA, potentially reducing transcription of target genes such as PITRM1. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate can cause hyperacetylation of histones, which could lead to a condensed chromatin state and a consequent decrease in PITRM1 gene expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
As an inhibitor of JNK, SP600125 could interfere with transcription factors that are phosphorylated by JNK and are crucial for PITRM1 gene expression, leading to reduced expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 inhibits PI3K, which could lead to a reduction in the activity of downstream transcription factors that are essential for the expression of the PITRM1 gene. | ||||||