PIPK III Inhibitors
Chemical inhibitors of PIPK III target various aspects of its function by interfering with different molecules and pathways that are crucial for its activity. Alendronate disrupts the mevalonate pathway, which is essential for the prenylation of small GTPases. These GTPases are necessary for the reorganization of the actin cytoskeleton and membrane trafficking, processes in which PIPK III is involved. LY294002 and Wortmannin are both PI3K inhibitors that block the PI3K/Akt pathway, preventing PIPK III from generating PIP3, a substrate necessary for down-stream signaling pathways.
Moreover, ML141 and NSC23766 inhibit Cdc42 and Rac1, respectively, both of which are GTPases that interact with PIPK III, leading to a reduction in the downstream effects necessary for PIPK III's role in cytoskeletal organization. IPA-3 targets PAK1, a kinase downstream of PIPK III in the actin polymerization pathway, and by inhibiting PAK1, it disrupts the actin polymerization process regulated by PIPK III. CK-666 inhibits the Arp2/3 complex, affecting PIPK III's role in actin nucleation and cytoskeleton assembly. PF-573228 inhibits FAK, which is involved in focal adhesion dynamics, indirectly affecting PIPK III function in cell adhesion and migration. Y-27632, a ROCK inhibitor, impacts stress fiber formation and cell contractility processes where PIPK III is implicated. ZCL278, as a Cdc42-GEF inhibitor, affects the actin cytoskeleton remodeling and membrane trafficking influenced by PIPK III. Lastly, SMIFH2 inhibits the formin family of proteins, mediating actin assembly and thereby indirectly inhibiting the function of PIPK III in regulating actin dynamics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alendronate acid | 66376-36-1 | sc-337520 | 5 g | $135.00 | 2 | |
Alendronate, a bisphosphonate, can inhibit PIPK III by acting on the mevalonate pathway, reducing the prenylation of small GTPases, which are essential for actin cytoskeleton reorganization and membrane trafficking, processes in which PIPK III is involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which curtails the PI3K/Akt pathway. As PIPK III is involved in PI3K signaling, its inhibition can prevent PIPK III from generating phosphatidylinositol (3,4,5)-trisphosphate (PIP3), a substrate necessary for its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is also a PI3K inhibitor and operates similarly to LY294002. It obstructs the PI3K/Akt pathway, thereby impeding PIPK III's ability to produce PIP3, a critical molecule in various signaling pathways reliant on PIPK III action. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 is a Cdc42 inhibitor, a small GTPase associated with actin cytoskeleton dynamics. By inhibiting Cdc42, ML141 can reduce the downstream effects that are necessary for PIPK III's role in cytoskeletal organization. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $92.00 $449.00 | 6 | |
IPA-3 selectively inhibits PAK1, a kinase downstream of PIPK III in the actin polymerization pathway. By inhibiting PAK1, IPA-3 disrupts the pathway's integrity, thereby inhibiting the functional role of PIPK III in cytoskeletal rearrangements. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
CK-666 is an Arp2/3 complex inhibitor. As PIPK III is involved in actin nucleation via the Arp2/3 complex, inhibition of this complex will impede PIPK III's ability to influence actin cytoskeleton assembly. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that affects stress fiber formation and cell contractility, where PIPK III is implicated. Through inhibiting ROCK, Y-27632 can impede the downstream processes in which PIPK III participates. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
ZCL278 is a Cdc42-GEF inhibitor, which by inhibiting the activation of Cdc42, can affect the actin cytoskeleton remodeling and membrane trafficking that PIPK III is known to influence. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is an inhibitor of the formin family of proteins, which mediate actin assembly. Since PIPK III plays a role in regulating actin dynamics, formin inhibition by SMIFH2 can indirectly inhibit the function of PIPK III. | ||||||