Pim-2 Activators
Pim-2 activators refer to a class of chemical compounds that have the capability to interact with and modulate the activity of the Pim-2 kinase enzyme. Pim-2, short for Proviral Integration site for Moloney murine leukemia virus-2, is a member of the Pim family of serine/threonine kinases. These enzymes play a significant role in regulating various cellular processes, including cell growth, survival, differentiation, and apoptosis. Pim-2, in particular, is known for its involvement in the regulation of cell cycle progression and is often associated with the promotion of cell survival and anti-apoptotic mechanisms.
The activation of Pim-2 by specific compounds can result in the phosphorylation of target proteins, leading to downstream signaling events that influence cellular behavior and functions. Pim-2 activators may achieve this activation by binding to the enzyme and modifying its conformation or by enhancing its catalytic activity. These compounds are valuable tools in research settings for investigating the intricate regulatory networks that control cell growth and survival. Understanding how Pim-2 activators influence cellular processes provides insights into the molecular mechanisms underlying cell proliferation and survival, which have implications in various areas of cell biology and cancer research. The study of Pim-2 activators is of great interest to researchers aiming to unravel the complexities of cellular signaling pathways and their involvement in various physiological and pathological conditions. By dissecting the role of Pim-2 and its activation, scientists can gain a deeper understanding of the molecular underpinnings of cancer, immune system regulation, and other cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of PI3K, LY294002 indirectly influences Pim-2 activity by modulating the PI3K/Akt pathway, which is known to regulate Pim-2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, TSA can alter gene expression patterns, potentially influencing Pim-2 expression indirectly. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor may upregulate Pim-2 indirectly by altering the epigenetic regulation of genes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
While primarily a p38 MAPK inhibitor, its impact on cellular signaling pathways might indirectly modulate Pim-2 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Known for inhibiting mTOR, Rapamycin could indirectly affect Pim-2 levels through its extensive regulatory effects on cell growth and survival pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, another MAPK pathway component, which could indirectly influence Pim-2 activity. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
This glucose analog can interfere with glycolysis and thereby influence various signaling pathways, potentially affecting Pim-2 expression. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
A SERCA pump inhibitor, it elevates cytosolic calcium levels, which could indirectly affect Pim-2 through calcium-dependent signaling pathways. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
As a proteasome inhibitor, Bortezomib can affect numerous cellular pathways, potentially altering Pim-2 activity indirectly. | ||||||
Nilotinib | 641571-10-0 | sc-202245 sc-202245A | 10 mg 25 mg | $205.00 $405.00 | 9 | |
Primarily a BCR-ABL tyrosine kinase inhibitor, its broad effects on signaling may indirectly modulate Pim-2. | ||||||