PIGF-2 Inhibitors
PIGF-2 inhibitors are a class of compounds specifically designed to inhibit the function of the Phosphatidylinositol Glycan Anchor Biosynthesis Class F protein 2 (PIGF-2), an essential enzyme involved in the GPI (glycosylphosphatidylinositol) anchor biosynthesis pathway. GPI anchors play a critical role in tethering various proteins to the cell membrane, which is vital for their proper localization and function. PIGF-2 is involved in a key step where it facilitates the transfer of ethanolamine phosphate to the glycan core, a process that is essential for the formation of mature GPI anchors. Inhibition of PIGF-2 disrupts this biosynthesis, leading to impaired GPI anchor formation and consequently mislocalization of GPI-anchored proteins. This mislocalization can alter cellular functions by affecting protein trafficking, membrane stability, and interactions with other molecules on the cell surface.
By using PIGF-2 inhibitors, researchers can study the impact of GPI anchor biosynthesis on various biological processes, such as signal transduction, cell adhesion, and immune responses. GPI-anchored proteins are involved in numerous cellular pathways, and their absence due to inhibited PIGF-2 function can provide insights into the roles these proteins play in maintaining cellular integrity and communication. These inhibitors offer a tool for dissecting the specific contributions of GPI-anchored proteins in complex cellular systems, allowing scientists to explore how alterations in GPI anchor biosynthesis can influence cellular behavior, organization, and response to external stimuli. In addition, PIGF-2 inhibitors contribute to a deeper understanding of the biosynthetic pathway itself, illuminating the molecular details of how GPI anchors are assembled and maintained in the cellular context.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can cause demethylation of the PIGF-2 gene promoter, potentially leading to the repression of its transcriptional activity and thus decreasing PIGF-2 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylase, Trichostatin A promotes a more condensed chromatin state around the PIGF-2 gene, resulting in reduced transcription and lower PIGF-2 protein levels. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib could lead to the accumulation of misfolded proteins, triggering cellular stress responses that may downregulate PIGF-2 expression as a secondary effect. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Thalidomide has been shown to repress the transcription of several growth factors; it could potentially downregulate PIGF-2 by interfering with specific transcription factors. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $49.00 $367.00 $2030.00 | 18 | |
Lenalidomide might inhibit the expression of PIGF-2 by modulating the activity of specific factors responsible for the transcription of the PIGF-2 gene. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $150.00 $920.00 | 5 | |
Sunitinib may obstruct tyrosine kinase activity essential for signal transduction involved in PIGF-2 expression, thereby reducing its synthesis at a transcriptional level. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is known to bind mTOR complex 1 and may reduce PIGF-2 expression by hindering the pathway that governs cell growth and proliferation, which includes PIGF-2 synthesis. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib may reduce PIGF-2 expression by selectively inhibiting tyrosine kinases that are upstream regulators of the gene expression machinery for PIGF-2. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid could decrease PIGF-2 expression by altering histone acetylation patterns specifically at the PIGF-2 gene locus, thereby repressing its expression. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK which in turn may inhibit mTOR signaling, leading to a decrease in the cap-dependent translation process that includes synthesis of proteins like PIGF-2. | ||||||