PIG-Z Activators
PIG-Z activators constitute a specialized group of chemical compounds that specifically target and enhance the activity of PIG-Z, a phosphatidylinositol glycan anchor biosynthesis class Z enzyme. This enzyme is part of the glycosylphosphatidylinositol (GPI) anchor biosynthesis pathway, a complex process responsible for the post-translational modification and anchoring of a variety of proteins to the cell surface. GPI anchors are critical for the proper localization, function, and stability of many proteins involved in diverse cellular processes, including signal transduction, cell adhesion, and immune response. Activators of PIG-Z are designed to increase the enzymatic efficiency of PIG-Z, thereby potentially influencing the production and function of GPI-anchored proteins. The chemical makeup of these activators can vary widely, encompassing small molecules, peptides, and possibly larger biomolecules, each interacting with the PIG-Z enzyme to modulate its activity in a specific manner, which in turn could affect the overall GPI anchor biosynthesis pathway and the repertoire of GPI-anchored proteins on the cell surface.
The investigation of PIG-Z activators involves a multidisciplinary approach, integrating aspects of enzymology, biochemistry, and cell biology to elucidate their mechanism of action and the subsequent cellular effects. Researchers delve into the molecular interactions between PIG-Z activators and the enzyme, examining how these interactions alter the enzyme's conformation, catalytic activity, and specificity towards its substrates. This includes detailed studies on the binding sites, affinity, and induced structural changes within PIG-Z, using techniques such as X-ray crystallography, enzyme kinetics assays, and surface plasmon resonance. Additionally, the impact of PIG-Z activation on the biosynthesis and function of GPI-anchored proteins is assessed through various cellular and molecular assays, helping to understand the broader implications of modulating this pathway. Through such comprehensive studies, insights into the complex regulation of GPI anchor biosynthesis are gained, shedding light on the intricate network of protein modifications that play a crucial role in cellular physiology and the maintenance of cellular integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A vitamin A derivative that regulates gene transcription by activating nuclear receptors, potentially affecting a wide range of genes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An adenylate cyclase activator that increases cAMP levels, which may lead to changes in gene expression through protein kinase A. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
An activator of protein kinase C that can modulate gene expression across various signaling pathways. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can alter the methylation status of DNA, potentially affecting gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A stilbenoid that may activate sirtuins and influence gene expression related to metabolism and stress response. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A soy isoflavone that acts as a protein tyrosine kinase inhibitor and could potentially influence multiple signaling pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that can alter chromatin structure and affect the expression of numerous genes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A short-chain fatty acid that acts as an HDAC inhibitor and may influence gene expression by affecting chromatin accessibility. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A synthetic glucocorticoid that binds to the glucocorticoid receptor, potentially influencing the expression of target genes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol from green tea that may affect various signaling pathways and alter gene expression profiles. | ||||||