PIG-L Activators
Compounds cholera toxin and pertussis toxin act by modifying G protein signaling, which can result in altered cAMP levels. Since cAMP is a common second messenger involved in various cellular processes, including those that may govern GPI-anchor protein function, changes in cAMP levels can affect the pathways in which PIG-L is involved. Methyl 2-methoxy-5-sulfamoylbenzoate, fumonisin B1, and myriocin target different aspects of lipid biosynthesis and modification, which can have ramifications for the membrane distribution and function of GPI-anchored proteins.
Brefeldin A and swainsonine intervene in Golgi apparatus processing, impacting the maturation of GPI-anchored proteins, while forskolin directly increases cAMP to promote related signaling pathways. Tunicamycin's inhibition of N-linked glycosylation and Miglustat hydrochloride inhibition of glucosylceramide synthase can influence the glycosylation patterns and lipid composition associated with GPI-anchored proteins. Furthermore, compounds like Filipin III and progesterone are known to perturb lipid rafts, cholesterol-rich membrane microdomains wheremany GPI-anchored proteins reside. Disruption of these microdomains can lead to changes in the localization and function of GPI-anchored proteins, potentially affecting the activity of proteins involved in their biosynthesis, including PIG-L.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Catalyzes ADP-ribosylation of Gi/o proteins, affecting cAMP levels and possibly influencing signaling related to GPI-anchored proteins. | ||||||
Fumonisin B1 | 116355-83-0 | sc-201395 sc-201395A | 1 mg 5 mg | $200.00 $680.00 | 18 | |
Inhibits ceramide synthase, altering sphingolipid biosynthesis, which can affect membrane microdomains associated with GPI-anchored proteins. | ||||||
Myriocin (ISP-1) | 35891-70-4 | sc-201397 | 10 mg | $150.00 | 8 | |
Inhibits serine palmitoyltransferase, potentially altering sphingolipid levels and membrane environments of GPI-anchored proteins. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts Golgi apparatus function, which can influence the post-translational processing and localization of GPI-anchored proteins. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Inhibits Golgi alpha-mannosidase II, potentially affecting the glycosylation and function of GPI-anchored proteins. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Inhibits N-linked glycosylation, which can affect the maturation and function of GPI-anchored proteins. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $118.00 $148.00 | 26 | |
Binds to sterols, disrupting lipid rafts, which can alter the membrane environment and signaling of GPI-anchored proteins. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Influences lipid raft composition and dynamics, which can modify the activity of associated GPI-anchored proteins. | ||||||