PICT-1 Activators
PICT-1 Activators encompass a specific selection of chemical compounds that are known to enhance the functional activity of the protein PICT-1, which is encoded by the gene PICT1. The biochemical mechanisms through which these activators function are multifarious, yet they share the common goal of amplifying PICT-1's cellular role without altering its expression levels. These activators typically engage with various intracellular signaling pathways, impacting the molecular interactions and modifications that govern PICT-1's activity. For instance, certain activators might phosphorylate specific residues on PICT-1 or its interacting partners, thereby enhancing PICT-1's ability to stabilize other proteins or to participate in protein complexes that are essential to cellular homeostasis. Others may bind allosterically to PICT-1, inducing conformational changes that potentiate its interaction with other cellular components and thus bolster its functional capacity. These activators are not mere facilitators of PICT-1's existing functions; they act to fine-tune the protein's activity, ensuring that PICT-1 can execute its cellular duties with greater efficacy.
The specificity of PICT-1 Activators is integral to their mode of action, as each activator targets distinct aspects of the protein's regulatory mechanisms. Some might influence the cellular localization of PICT-1, guiding it to particular subcellular domains where it performs crucial roles. Others might enhance PICT-1's stability by protecting it from proteasomal degradation, ensuring a sustained presence within the cellular milieu. The interplay between these activators and the cellular signaling networks that intersect with PICT-1's pathway is complex, involving a cascade of intracellular events that ultimately lead to the upregulated activity of PICT-1. By modulating various signaling molecules and pathways, PICT-1 Activators ensure the protein is optimally positioned to carry out its functions, which can range from protein synthesis regulation to maintaining genomic stability. These compounds achieve the functional activation of PICT-1 by creating a cellular environment that is conducive to its action, thereby underpinning the efficient operation of the processes PICT-1 influences.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol found in red grapes, has been shown to activate SIRT1, which in turn can deacetylate specific lysine residues on PICT-1, enhancing its activity in pathways related to DNA damage response and ribosome biogenesis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can lead to hyperacetylation of histones, thereby potentially affecting the chromatin structure around the NOP53 gene, indirectly facilitating PICT-1's increased interaction with chromatin remodeling complexes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can reduce ribosomal protein biosynthesis. Since PICT-1 is associated with ribosome biogenesis, the inhibition of ribosomal protein synthesis by rapamycin may enhance the relative necessity and functional activity of PICT-1. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, which can lead to a variety of downstream effects on cellular metabolism. Enhanced AMPK activity can increase the functional requirements for PICT-1 in adapting ribosome biogenesis to energy availability. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN is a precursor in the NAD+ biosynthesis pathway and can enhance SIRT1 activity. Increased SIRT1 activity may promote PICT-1's involvement in DNA repair processes by modulating its post-translational modifications. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium induces autophagy and may influence ribosomal biogenesis, which could indirectly enhance the functional activity of PICT-1 by increasing the need for ribosome assembly and maintenance, processes that PICT-1 is involved in. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMPK activator that mimics the cellular energy deficit condition, potentially upregulating the functional activity of PICT-1 as the cell adapts its ribosome biogenesis machinery in response to metabolic stress. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, acts as a histone deacetylase inhibitor, potentially increasing the expression of NOP53 gene and thereby enhancing the activity of its protein product PICT-1 in ribosome biogenesis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate multiple signaling pathways, including those regulating autophagy and apoptosis. This modulation can indirectly enhance the activity of PICT-1 by affecting the cellular processes in which it is involved, particularly under stress conditions. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine inhibits autophagy by disrupting lysosome acidification, potentially enhancing the role of PICT-1 in compensating for impaired degradation pathways and maintaining protein and organelle quality control. | ||||||