PICT-1 Inhibitors
PICT-1 inhibitors belong to a specialized class of chemical compounds designed to target the PICT-1 (Protein Interacting with Carboxyl Terminus 1) protein. PICT-1 is a multifunctional protein involved in various cellular processes, including gene expression regulation and protein translation. It is known to interact with several key proteins, such as ribosomal protein L5 (RPL5) and nucleolin, and plays a role in modulating ribosome biogenesis and the assembly of ribonucleoprotein complexes. Additionally, PICT-1 has been implicated in the regulation of apoptosis and cellular stress responses, further highlighting its versatile functions within the cell.
Inhibitors of PICT-1 are designed to interact with this protein and disrupt its interactions with other cellular components or its functions in various cellular processes. These inhibitors may operate through different mechanisms, such as binding to specific domains of PICT-1 or altering its conformation. By inhibiting PICT-1, these compounds affect ribosome biogenesis, protein translation, and other processes involving PICT-1, ultimately influencing cell function and physiology. Research on PICT-1 inhibitors is primarily focused on unraveling the intricate molecular mechanisms by which PICT-1 participates in diverse cellular processes, contributing to our understanding of gene expression regulation, ribosome assembly, and cellular stress responses in a broader cellular context.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Binds to DNA and inhibits RNA synthesis, potentially reducing PICT-1 expression by preventing its transcription. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Selectively inhibits RNA polymerase II, potentially decreasing mRNA synthesis of PICT-1. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Interacts with DNA by intercalation and inhibits topoisomerase II, which could disrupt transcription of PICT-1. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $99.00 | 5 | |
Adenosine analog that can terminate RNA chain elongation, potentially affecting PICT-1 mRNA levels. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Inhibits inosine monophosphate dehydrogenase, which could lead to reduced guanine nucleotide levels and affect PICT-1 expression. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Causes premature chain termination during translation, which could lead to decreased PICT-1 protein levels. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Inhibits peptidyl transferase activity of the ribosome, preventing protein elongation, and may reduce PICT-1 synthesis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic ribosomal translocation, which could decrease PICT-1 protein synthesis. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Inhibits RNA polymerase II, potentially reducing transcription of PICT-1. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Plant alkaloid reported to inhibit DNA and RNA synthesis, which could affect PICT-1 expression. | ||||||