PIAS 3 Activators
The chemical class of PIAS 3 activators encompasses a diverse array of compounds that influence PIAS 3 either directly or indirectly through intricate cellular pathways. PIAS 3, a member of the Protein Inhibitor of Activated STAT (PIAS) family, acts as a SUMO E3 ligase and participates in the regulation of various cellular processes, including transcriptional activation and protein sumoylation. Ruxolitinib, a JAK1/2 inhibitor, indirectly activates PIAS 3 by influencing the JAK-STAT signaling pathway. This pathway plays a crucial role in cellular responses to cytokines and growth factors, and PIAS 3 is intricately involved in modulating STAT proteins' activities within this pathway. Similarly, Fludarabine, a nucleoside analog, indirectly activates PIAS 3 by affecting DNA synthesis and repair, impacting processes that PIAS 3 regulates in response to DNA damage.
The chemical class also includes compounds like Curcumin, Leflunomide, and JSH-23, which indirectly activate PIAS 3 through anti-inflammatory mechanisms. Curcumin, a natural compound with anti-inflammatory properties, influences pathways associated with inflammation, affecting the recruitment and function of PIAS 3 in the regulation of transcription factors involved in inflammatory responses. Furthermore, compounds such as PFI-3, ML-792, and I-BET151 target specific proteins (SETD7, MLL1, BET bromodomains) to indirectly modulate PIAS 3 activity. These compounds highlight the intricate interplay between PIAS 3 and epigenetic regulators or chromatin remodelers, emphasizing the multifaceted nature of PIAS 3 activation. Overall, the chemical class of PIAS 3 activators showcases a strategic selection of compounds that, through various pathways, impact PIAS 3 function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Ruxolitinib is a JAK1/2 inhibitor affecting the JAK-STAT signaling pathway. Its impact on JAK-STAT signaling can indirectly activate PIAS 3, as PIAS 3 regulates the activity of STAT proteins, and modulation of JAK-STAT signaling can influence the recruitment and function of PIAS 3. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $57.00 $200.00 | 15 | |
Fludarabine is a nucleoside analog affecting DNA synthesis and repair. Its impact on DNA-related processes can indirectly activate PIAS 3, as PIAS 3 is involved in the regulation of transcription factors with roles in DNA damage response, and modulation of DNA processes can influence the recruitment and function of PIAS 3. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a natural compound with anti-inflammatory properties. Its impact on inflammatory pathways can indirectly activate PIAS 3, as PIAS 3 is involved in the regulation of inflammation-associated transcription factors, and modulation of inflammatory signaling can influence the recruitment and function of PIAS 3. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $81.00 | 5 | |
Leflunomide is a dihydroorotate dehydrogenase inhibitor affecting pyrimidine synthesis. Its impact on pyrimidine synthesis can indirectly activate PIAS 3, as PIAS 3 is implicated in processes related to cell proliferation, and modulation of pyrimidine synthesis can influence the recruitment and function of PIAS 3. | ||||||
PFI 3 | 1819363-80-8 | sc-507340 | 10 mg | $300.00 | ||
PFI-3 is a chemical compound inhibiting the SETD7 methyltransferase. Its impact on SETD7 inhibition can indirectly activate PIAS 3, as PIAS 3 interacts with SETD7, and modulation of SETD7 activity can influence the recruitment and function of PIAS 3 in the regulation of protein methylation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a BET bromodomain inhibitor affecting chromatin structure. Its impact on chromatin dynamics can indirectly activate PIAS 3, as PIAS 3 is involved in the regulation of transcription factors associated with chromatin remodeling, and modulation of chromatin structure can influence the recruitment and function of PIAS 3. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $210.00 $252.00 $1740.00 $1964.00 | 34 | |
Also called JSH-23, this compound is an inhibitor of NF-κB translocation. Its impact on NF-κB signaling can indirectly activate PIAS 3, as PIAS 3 regulates NF-κB activity, and modulation of NF-κB translocation can influence the recruitment and function of PIAS 3 in the regulation of immune responses and inflammation. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is a BET bromodomain inhibitor affecting chromatin structure. Its impact on chromatin dynamics can indirectly activate PIAS 3, as PIAS 3 is involved in the regulation of transcription factors associated with chromatin remodeling, and modulation of chromatin structure can influence the recruitment and function of PIAS 3. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 is a NEDD8-activating enzyme (NAE) inhibitor affecting protein neddylation. Its impact on neddylation can indirectly activate PIAS 3, as PIAS 3 is involved in the regulation of proteins associated with the neddylation pathway, and modulation of neddylation can influence the recruitment and function of PIAS 3. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Thalidomide is an immunomodulatory drug with anti-inflammatory properties. Its impact on inflammatory pathways can indirectly activate PIAS 3, as PIAS 3 is involved in the regulation of inflammation-associated transcription factors, and modulation of inflammatory signaling can influence the recruitment and function of PIAS 3. | ||||||