PHKA1 Inhibitors
PHKA1 inhibitors encompass a diverse range of chemical compounds that, through various mechanisms, reduce the functional activity of the phosphorylase kinase regulatory subunit alpha 1. These inhibitors target specific signaling pathways and enzymatic activities that are crucial for the activation and function of PHKA1. For instance, certain inhibitors impede the action of protein kinases responsible for the phosphorylation and activation of this regulatory subunit, thereby attenuating its activity. Others selectively inhibit protein kinase A (PKA) or protein kinase C (PKC), each playing a key role in the phosphorylation processes that modulate PHKA1 activity. By blocking these kinases, the inhibitors effectively decrease the functional output of PHKA1. Additional inhibitors focus on enzymes like myosin light chain kinase (MLCK) and phosphoinositide 3-kinases (PI3K), both indirectly linked to the regulation of glycogen metabolism, wherein PHKA1 is a pivotal participant.
Moreover, the repertoire of PHKA1 inhibitors includes compounds that target broader signaling networks, such as those mediated by p38 MAPK, mTOR, and AMP-activated protein kinase (AMPK). Inhibition of these pathways leads to a cascade of effects that ultimately downregulate PHKA1 activity. The inhibition of mTOR, for instance, disrupts a pathway that indirectly affects PHKA1's regulatory functions. Similarly, blocking AMPK alters the cellular energy balance, which can influence PHKA1's involvement in glycogen synthesis and breakdown. Other compounds act on calcium signaling pathways or glycogen synthase kinase 3β (GSK-3β), which are also indirectly associated with the regulation of PHKA1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that inhibits a wide range of protein kinases, including those involved in the phosphorylation of PHKA1. By inhibiting these kinases, this compound may reduce the phosphorylation and therefore the activity of PHKA1. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
A selective inhibitor of protein kinase A (PKA) which is involved in the activation of PHKA1 through phosphorylation processes. Inhibition of PKA results in decreased activation of PHKA1. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Known to inhibit protein kinase C (PKC) which can phosphorylate substrates that may regulate PHKA1 activity. By inhibiting PKC, this compound can indirectly inhibit the function of PHKA1. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
An inhibitor of myosin light chain kinase (MLCK) which is implicated in muscle contraction and indirectly in glycogen metabolism, therefore can influence the activity of PHKA1 involved in glycogen phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A phosphoinositide 3-kinases (PI3K) inhibitor that can affect the downstream insulin signaling pathways, indirectly impacting the regulatory processes of PHKA1 in glycogen metabolism. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor that by inhibiting PI3K can alter insulin signaling pathways, consequently affecting PHKA1's regulatory role in glycogenolysis. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
An inhibitor of p38 MAPK, involved in stress-activated pathways that can influence the activity of PHKA1, leading to the reduced functional activity of PHKA1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits the mammalian target of rapamycin (mTOR), which is a part of the pathway that can regulate protein synthesis and has indirect implications on the function of PHKA1. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
An AMP-activated protein kinase (AMPK) inhibitor which plays a crucial role in cellular energy homeostasis and may interact with pathways regulating PHKA1 activity. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
A broad-spectrum PKC inhibitor that through its action can modify the phosphorylation state of proteins involved in the regulation of PHKA1. | ||||||