PHF3 Activators
PHF3 Activators comprise a specific set of chemical compounds that indirectly augment the functional activity of PHF3. The activation of protein kinase A by Forskolin creates a signaling environment conducive to PHF3 activation by phosphorylating proteins that may interact with PHF3, thus enhancing its role in chromatin remodeling and transcriptional regulation. Genistein, by inhibiting tyrosine kinases, reduces competition for phosphorylation, allowing for PHF3's indirect activation. The engagement of sphingosine-1-phosphate receptors by Sphingosine-1-phosphate initiates signaling cascades, potentially culminating in transcriptional or post-translational modifications that enhance PHF3's functional role. Similarly, Thapsigargin, by increasing intracellular calcium, can activate pathways that lead to the enhancement of PHF3's activity, which is vital for its role in gene expression regulation.
Additionally, PHF3's activity is modulated by signaling molecules that influence kinase activity. PMA, through the activation of PKC, leads to the phosphorylation of proteins within pathways that can indirectly activate PHF3. The inhibition of PI3K by both LY294002 and Wortmannin may alleviate negative regulatory effects on PHF3, leading to its enhanced activity. Epigallocatechin gallate (EGCG) inhibits kinases that could negatively regulate PHF3, thereby indirectly enhancing its function. SB203580 and U0126 modulate MAPK signaling pathways, shifting the equilibrium to favor pathways that enhance PHF3's activity in gene regulation. A23187, by raising intracellular calcium levels, and Staurosporine, by inhibiting a broad spectrum of protein kinases, potentially enhance PHF3 activity by activating downstream signaling pathways or lifting inhibition on processes in which PHF3 is involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels, which indirectly enhances PHF3 activity by activating PKA. PKA then phosphorylates substrates that may interact with or modify PHF3, leading to its functional activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein acts as a tyrosine kinase inhibitor, which can reduce competitive phosphorylation events that might otherwise suppress PHF3 activity, thereby indirectly increasing PHF3's functional activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate engages with sphingosine-1-phosphate receptors, triggering signaling cascades that could lead to transcriptional events or post-translational modifications that enhance PHF3 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, leading to increased intracellular calcium levels that could activate calcium-dependent pathways, indirectly enhancing PHF3 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which may lead to phosphorylation of proteins involved in pathways that enhance PHF3 activity, such as chromatin modification or transcriptional regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, altering downstream signaling pathways, such as AKT, which may relieve negative regulation on PHF3, indirectly enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, as a kinase inhibitor, may inhibit kinases that negatively regulate PHF3, thereby indirectly enhancing PHF3 activity through reduced inhibitory phosphorylation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 specifically inhibits p38 MAPK, which could shift signaling dynamics to favor pathways that upregulate PHF3 activity or enhance its functional role in gene expression regulation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as a calcium ionophore, raising intracellular calcium levels, which can activate calcium-dependent signaling pathways that might enhance the activity of PHF3. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, similar to LY294002, which can indirectly lead to the enhancement of PHF3 activity by modulating downstream pathways such as those involved in cell growth and survival. | ||||||