PHF20 Activators
The chemicals listed are primarily epigenetic modifiers that influence DNA methylation, histone acetylation, and histone methylation. They do not directly activate PHF20 but can modulate the chromatin environment, which is crucial for PHF20's function in gene regulation and chromatin remodeling. HDAC inhibitors like Trichostatin A, Vorinostat, Valproic Acid, Sodium Butyrate, Entinostat, and Panobinostat increase histone acetylation, leading to a more open chromatin structure. This alteration can potentially enhance PHF20's ability to interact with chromatin, thereby influencing its role in gene expression regulation. DNA methyltransferase inhibitors such as 5-Azacytidine and RG108 reduce DNA methylation, leading to changes in chromatin structure and gene expression. These changes could indirectly affect the functional dynamics of PHF20, especially in regions of the genome where DNA methylation is altered.
Compounds like Disulfiram and BIX-01294, which inhibit histone demethylases and methyltransferases, respectively, also impact chromatin states. By altering histone methylation, they can influence PHF20's interactions with chromatin. Furthermore, JQ1, a BET bromodomain inhibitor, disrupts the reading of acetylated histones, affecting chromatin organization and potentially impacting PHF20's function. These chemicals collectively offer a broad perspective on modulating the chromatin environment, indirectly influencing PHF20's activity. Their actions highlight the complex interplay between chromatin dynamics and the regulation of gene expression, with PHF20 being an integral part of this intricate network.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that causes hypomethylation of DNA. This alteration in DNA methylation status can lead to changes in chromatin structure and gene expression patterns, potentially affecting the regulatory roles of PHF20 in gene transcription and chromatin remodeling. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A (TSA) is a histone deacetylase (HDAC) inhibitor. By inhibiting HDAC, TSA increases the acetylation of histones, leading to a more open chromatin structure and potentially influencing the activity of chromatin-associated proteins like PHF20. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Similar to TSA, Suberoylanilide Hydroxamic Acid is another HDAC inhibitor that promotes histone acetylation, thereby affecting chromatin structure. This can indirectly influence the function of PHF20 in the context of gene regulation and chromatin dynamics. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram has been shown to inhibit the activity of LSD1, a histone demethylase. By altering histone methylation status, disulfiram can indirectly influence chromatin remodeling processes and potentially the functional dynamics of PHF20. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
As an HDAC inhibitor, Valproic Acid increases histone acetylation, thereby affecting chromatin accessibility and potentially influencing PHF20's interaction with chromatin. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate is another HDAC inhibitor that leads to increased histone acetylation and can affect chromatin structure. This may alter the function of PHF20 in the context of chromatin remodeling and gene regulation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a BET bromodomain inhibitor that affects the reading of acetylated histones. By modulating the interaction between bromodomain proteins and acetylated histones, JQ1 can influence chromatin organization, potentially impacting PHF20's function. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 is an HDAC inhibitor that leads to increased acetylation of histones, thereby potentially influencing chromatin remodeling and PHF20's role in gene expression regulation. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is a potent HDAC inhibitor that affects histone acetylation and thereby influences chromatin architecture. This alteration can indirectly impact PHF20's activity in the nucleus. | ||||||