PheRS Inhibitors
PheRS inhibitors are a class of chemical compounds designed to target and inhibit the activity of phenylalanyl-tRNA synthetase (PheRS), an enzyme essential for protein synthesis in cells. PheRS is responsible for catalyzing the attachment of the amino acid phenylalanine to its corresponding tRNA molecule during translation. This process, known as aminoacylation, is a critical step in ensuring that phenylalanine is incorporated accurately into the growing polypeptide chain according to the mRNA sequence. By inhibiting PheRS, these compounds interfere with the aminoacylation process, disrupting the proper incorporation of phenylalanine into proteins, which can lead to errors in protein synthesis and cellular dysfunction.
PheRS inhibitors are widely used in research to explore the fundamental mechanisms of protein synthesis and to understand the broader effects of disrupted amino acid incorporation on cellular processes. By blocking PheRS activity, researchers can study how phenylalanine deficiency at the translational level impacts cellular metabolism, protein folding, and overall protein homeostasis. These inhibitors also provide insights into the specificity of aminoacyl-tRNA synthetases and the importance of precise amino acid-tRNA pairing for maintaining the fidelity of the genetic code. PheRS inhibitors serve as valuable tools for studying the critical role of aminoacyl-tRNA synthetases in translation, as well as the consequences of disrupting protein synthesis on cellular functions such as growth, division, and response to environmental cues. Through these studies, scientists can gain a deeper understanding of the intricate processes that govern gene expression and protein biosynthesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA sequences at transcription initiation complexes, which may result in the transcriptional repression of the PheRS gene by blocking RNA polymerase movement along the gene. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin can bind to the beta subunit of bacterial RNA polymerase, potentially causing a decrease in the synthesis of bacterial PheRS mRNA by obstructing the initiation of transcription. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
This compound could selectively inhibit RNA polymerase II in eukaryotic cells, leading to a decreased production of mRNA for PheRS by halting mRNA elongation. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB can suppress transcriptional elongation by RNA polymerase II, which may result in a reduced level of PheRS mRNA due to premature termination of its transcription. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide has been shown to inhibit the overall activity of RNA polymerase II, which could lead to a targeted downregulation of PheRS gene transcription. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C forms DNA adducts and crosslinks between DNA strands, which may obstruct the transcription machinery from accessing the PheRS gene, leading to decreased mRNA synthesis. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine's DNA intercalating activity could disrupt the proper transcription of the PheRS gene, potentially leading to a lower transcription rate and thus reduced expression of PheRS. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylase, causing an increase in acetylated histones, which may repress transcription of the PheRS gene by altering chromatin structure. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate has been found to inhibit DNA methyltransferases, which might lead to hypermethylation of the PheRS gene promoter and consequent transcriptional silencing of the gene. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, preventing DNA from unwinding, which is necessary for transcription; this action could specifically hinder the transcription of the PheRS gene. | ||||||