PHAX Activators
PHAX, short for phosphorylated adaptor for RNA export, is a pivotal protein in the cellular machinery of RNA processing and transport. It serves as an adaptor molecule that is essential for the nuclear export of small nuclear ribonucleoproteins (snRNPs), which are key components of the spliceosome-the complex responsible for splicing pre-messenger RNA (mRNA).Upon synthesis, PHAX binds to snRNPs in the nucleus. It undergoes phosphorylation, which is a critical modification that enables PHAX to interact with the export receptor CRM1 (also known as exportin-1). This interaction is necessary for the snRNPs to be recognized and transported through the nuclear pore complex into the cytoplasm. Once in the cytoplasm, the snRNPs are incorporated into the spliceosome to carry out their function in mRNA splicing.
The regulation of PHAX is tightly controlled and responsive to various cellular conditions. Its activity is modulated by phosphorylation status, which can be influenced by cellular signaling pathways that respond to stress, growth factors, and other intracellular signals. The precise expression levels of PHAX are crucial, as they ensure the proper assembly and function of the spliceosome, thereby maintaining the fidelity of gene expression.Disruptions in PHAX function or expression can lead to aberrant mRNA splicing and have been implicated in a range of diseases, including cancer and neurodegenerative disorders. Research into PHAX not only sheds light on the fundamental processes of gene expression but also opens potential avenues for diseases associated with splicing defects.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
It increases cAMP levels, potentially affecting signaling pathways that regulate gene expression, including PHAX. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A polyphenol that may influence gene expression related to cell signaling and mRNA processing. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
It affects GSK-3 signaling and may influence gene expression, including that of PHAX. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A derivative of vitamin A that modulates gene expression, potentially affecting PHAX expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, it can alter chromatin structure and gene expression, possibly affecting PHAX. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Another histone deacetylase inhibitor that can change gene expression, potentially affecting PHAX levels. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cAMP analog that may upregulate genes controlled by cAMP-responsive elements, including PHAX. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
An antimetabolite that can interfere with DNA synthesis and repair, potentially impacting gene expression profiles. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
A chemotherapy drug that causes DNA damage and could influence the expression of DNA repair genes and possibly PHAX. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
A selective estrogen receptor modulator that can alter the transcription of estrogen-responsive genes, potentially including PHAX. | ||||||