PGC-1α Activators
PGC-1α activators represent a diverse group of chemicals that modulate cellular pathways to enhance the activity of the Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha (PGC-1α). These compounds, including resveratrol, AICAR, and GW501516, exert their effects through intricate signaling networks. Resveratrol, for instance, engages the SIRT1/AMPK pathway, stimulating PGC-1α and promoting mitochondrial biogenesis. Similarly, AICAR activates PGC-1α indirectly by stimulating AMPK, contributing to enhanced mitochondrial function and fatty acid oxidation. The PGC-1α activator, GW501516, interacts with Peroxisome Proliferator-Activated Receptors (PPARs), specifically PPAR-δ, to induce PGC-1α expression. This activation leads to an upregulation of genes involved in mitochondrial biogenesis and energy metabolism. Berberine, another activator, operates through the AMPK pathway, enhancing mitochondrial function and biogenesis. This variety of mechanisms highlights the complexity of PGC-1α regulation by these chemicals, influencing multiple pathways to orchestrate a concerted enhancement of cellular energy metabolism.
Beyond direct activators, compounds like Oltipraz and sulforaphane indirectly support PGC-1α by modulating the NRF2 pathway. Oltipraz activates NRF2, leading to an antioxidant response that indirectly contributes to mitochondrial health and PGC-1α activation. Sulforaphane, on the other hand, activates PGC-1α through NRF2-dependent pathways, further illustrating the diverse strategies employed by these chemicals. Collectively, PGC-1α activators form a nuanced group of compounds that intricately regulate cellular processes, ultimately culminating in the activation of PGC-1α and the promotion of mitochondrial biogenesis and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound known for its activation of PGC-1α. It exerts its effects through the SIRT1/AMPK pathway, leading to increased mitochondrial biogenesis and enhanced oxidative phosphorylation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR, an AMP-activated protein kinase (AMPK) activator, indirectly activates PGC-1α by stimulating AMPK. This activation enhances mitochondrial function and promotes fatty acid oxidation in various tissues. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
A PPAR-δ agonist, GW501516 activates PGC-1α by binding to and activating PPAR-δ. This interaction induces the expression of genes involved in mitochondrial biogenesis and energy metabolism. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates PGC-1α through the AMPK pathway, enhancing mitochondrial function and biogenesis. It also modulates cellular metabolism by regulating various downstream targets of AMPK. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates PGC-1α by upregulating SIRT1 expression and activating AMPK. This dual mechanism enhances mitochondrial biogenesis and function, contributing to improved cellular energy metabolism. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz, a nuclear factor erythroid 2-related factor 2 (NRF2) activator, indirectly activates PGC-1α by promoting NRF2-mediated antioxidant responses. This indirectly supports mitochondrial health and function. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin, an AMPK activator, indirectly activates PGC-1α by stimulating AMPK. This activation enhances mitochondrial biogenesis and improves cellular energy metabolism, contributing to metabolic homeostasis. | ||||||
Honokiol | 35354-74-6 | sc-202653 sc-202653A | 10 mg 25 mg | $118.00 $178.00 | 4 | |
Honokiol activates PGC-1α by promoting SIRT3 expression and AMPK activation. This dual mechanism enhances mitochondrial function and biogenesis, contributing to improved cellular energy metabolism. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ indirectly activates PGC-1α by supporting SIRT1 activity. This coenzyme plays a crucial role in maintaining mitochondrial health and function, contributing to enhanced oxidative phosphorylation. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid activates PGC-1α through the AMPK pathway, promoting mitochondrial biogenesis and function. It also acts as an antioxidant, protecting mitochondria from oxidative stress-related damage. | ||||||