PGC1a Antibody (D-5): sc-518025

PGC-1α Antibody (D-5) is a mouse monoclonal IgG2a kappa light chain antibody designed to recognize PGC-1α proteins from mouse, rat, and human origins by targeting amino acids 1-300 near the N-terminus. PGC-1α, or Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, is a pivotal nuclear transcriptional coactivator that orchestrates the regulation of genes involved in energy metabolism, mitochondrial biogenesis, and adaptive thermogenesis. Located predominantly within the nucleus, PGC-1α′s nuclear presence is crucial as PGC-1α enables direct interaction with various transcription factors, facilitating precise control over gene expression in response to cellular energy demands and metabolic stress. This strategic localization allows PGC-1α to effectively coordinate cellular responses that maintain energy homeostasis and support mitochondrial function. Additionally, PGC-1α undergoes extensive post-translational modifications, including phosphorylation, acetylation, methylation, and ubiquitination, which are essential for modulating activity, stability, and interactions with other proteins. These modifications enable PGC-1α to dynamically respond to diverse cellular signals and environmental stimuli, ensuring flexible and efficient regulation of metabolic pathways. Anti-PGC-1α antibody (D-5) is an indispensable tool for researchers, offering robust performance in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). By facilitating detailed investigations into the multifaceted roles of PGC-1α, anti-PGC-1α antibody (D-5) supports advanced studies on metabolic regulation, mitochondrial dynamics, and the molecular mechanisms underlying various physiological and pathological processes, thereby contributing significantly to the understanding of cellular energy management and genomic integrity.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PGC1a Antibody (D-5) has 125 citations in a variety of scientific publications.

Primary antibodies like Anti-PGC1a Antibody (D-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PGC1a Antibody (D-5) Specifications

Alternate Product Name: PGC-1 alpha

Product Clone Name: D-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-300

Epitope Target: PGC-1α

Epitope Species: human

Product Reactivity/Detection: PGC-1α

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 125 citations in various scientific publications

Available Conjugates/Forms for PGC1a Antibody (D-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred PGC1a antibody is PGC1a Antibody (4A8): sc-517380.