PGC1a Antibody (4A8): sc-517380

PGC-1α Antibody (4A8) is a mouse monoclonal IgG2b kappa light chain antibody that specifically targets human PGC-1α, a key transcriptional co-activator crucial in regulating energy homeostasis, mitochondrial biogenesis, and thermogenesis. Anti-PGC-1α antibody (4A8) recognizes a recombinant protein corresponding to amino acids 689-798 of PGC-1α, a region integral to mediating protein-protein interactions. The structure of PGC-1α includes multiple functional domains, such as an N-terminal activation domain, an RNA recognition motif, a serine/arginine-rich region, and a C-terminal domain. These domains are critical for interacting with transcription factors like NRF-1 and PPARγ, which are essential in forming transcriptional complexes that control the expression of genes linked to oxidative metabolism. The structural features of PGC-1α enable regulation of chromatin remodeling, a process vital for adjusting cellular energy output in response to metabolic changes, making PGC-1α significant for understanding cellular energy regulation. PGC-1α monoclonal antibody (4A8) is validated for use in western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA), allowing for the detection and analysis of PGC-1α in human samples.

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PGC1a Antibody (4A8) References:

1. Coactivator and corepressor complexes in nuclear receptor function.  |  Xu, L., et al. 1999. Curr Opin Genet Dev. 9: 140-7. PMID: 10322133
2. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.  |  Wu, Z., et al. 1999. Cell. 98: 115-24. PMID: 10412986
3. Activation of PPARgamma coactivator-1 through transcription factor docking.  |  Puigserver, P., et al. 1999. Science. 286: 1368-71. PMID: 10558993
4. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes.  |  Vega, RB., et al. 2000. Mol Cell Biol. 20: 1868-76. PMID: 10669761
5. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.  |  Oñate, SA., et al. 1995. Science. 270: 1354-7. PMID: 7481822
6. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.  |  Torchia, J., et al. 1997. Nature. 387: 677-84. PMID: 9192892
7. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.  |  Puigserver, P., et al. 1998. Cell. 92: 829-39. PMID: 9529258

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PGC1a Antibody (4A8) has 56 citations in a variety of scientific publications.

Primary antibodies like Anti-PGC1a Antibody (4A8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PGC1a Antibody (4A8) Specifications

Alternate Product Name: PGC-1 alpha

Product Clone Name: 4A8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 689-798

Epitope Target: PGC-1α

Epitope Species: human

Product Reactivity/Detection: PGC-1α

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 56 citations in various scientific publications

Available Conjugates/Forms for PGC1a Antibody (4A8): N/A

The preferred PGC1a antibody is PGC1a Antibody (D-5): sc-518025.