Pex7p Inhibitors
Chemical inhibitors of Pex7p harness various biochemical pathways to impede its function. Triacsin C targets long-chain acyl-CoA synthetase, essential for producing acyl-CoA, thereby reducing the substrate availability for peroxisomal metabolism and indirectly affecting Pex7p activity. Perhexiline restricts the carnitine palmitoyltransferase system, which shuttles long-chain fatty acids into the mitochondria, leading to an intracellular buildup of these fatty acids that may disrupt peroxisomal processes involving Pex7p. Similarly, thioridazine impedes the uptake of long-chain fatty acids into peroxisomes, potentially altering the matrix composition and affecting the Pex7p import machinery's optimal function. Ginkgolic Acid, on the other hand, hampers the SUMOylation process. This post-translational modification is vital for numerous proteins, and if this modification is crucial for Pex7p or its cargo proteins, the inhibition by Ginkgolic Acid can affect Pex7p's role in protein import into peroxisomes.
Ebselen and Tetradecylthioacetic Acid exert their influence by modulating oxidative stress responses and β-oxidation pathways, respectively, which can lead to changes in the peroxisomal environment, potentially affecting Pex7p functionality. PPAR agonists, including Clofibrate, Fenofibrate, and Bezafibrate, promote peroxisome proliferation. This surge in peroxisomal biogenesis can lead to an overburdening of the organelle's import capacity, resulting in a backlog that hinders Pex7p's ability to facilitate the import of proteins into peroxisomes. Lovastatin, by inhibiting cholesterol synthesis, can alter peroxisomal membrane properties, potentially compromising Pex7p's interaction with the peroxisomal membrane and its associated import complexes. Lastly, Leptomycin B, although primarily an inhibitor of nuclear export, can indirectly influence Pex7p by affecting the cellular distribution and levels of transcription factors, which are vital for the expression of peroxisomal proteins, thereby impacting Pex7p's functional capacity within the peroxisome.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $149.00 $826.00 | 14 | |
Triacsin C inhibits long-chain acyl-CoA synthetase, which is crucial for the synthesis of acyl-CoA. Since Pex7p is involved in peroxisomal biogenesis and the import of specific types of enzymes into the peroxisomes, the inhibition of acyl-CoA synthetase could lead to a reduction in the levels of acyl-CoA derivatives required for peroxisomal metabolism, thus indirectly inhibiting Pex7p's function in peroxisomal processes. | ||||||
rac Perhexiline Maleate | 6724-53-4 | sc-460183 | 10 mg | $184.00 | ||
Perhexiline inhibits carnitine palmitoyltransferase (CPT) 1 and 2, enzymes involved in the transport of long-chain fatty acids into the mitochondria. As peroxisomes also play a role in fatty acid metabolism, blocking mitochondrial fatty acid uptake could lead to an accumulation of long-chain fatty acids within the cell, potentially disrupting peroxisomal function and indirectly inhibiting Pex7p-dependent processes. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate is a peroxisome proliferator-activated receptor (PPAR) agonist, and while it primarily acts to upregulate peroxisome proliferation, it could theoretically overload the peroxisomal import machinery, leading to a dysfunctional state where Pex7p is unable to effectively import its cargo proteins due to the increased demand, indirectly inhibiting its function. | ||||||
Thioridazine | 50-52-2 | sc-473180 | 50 mg | $500.00 | ||
Thioridazine is an antipsychotic that has been found to inhibit the uptake of long-chain fatty acids into peroxisomes. As Pex7p is involved in the import of proteins into peroxisomes, thioridazine's effect on fatty acid import could indirectly inhibit Pex7p by disrupting peroxisomal matrix composition and function. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate activates PPAR alpha and may induce peroxisome proliferation. Similar to clofibrate, fenofibrate could indirectly inhibit Pex7p by potentially overburdening the peroxisomal import machinery, thereby leading to a backlog of protein import and inhibiting Pex7p's function. | ||||||
Ginkgolic acid C15:1 | 22910-60-7 | sc-235249 | 5 mg | $306.00 | 2 | |
Ginkgolic Acid is known to inhibit SUMOylation, a post-translational modification process. If Pex7p or its associated cargo proteins require SUMOylation for proper function, then ginkgolic acid could inhibit Pex7p function indirectly by preventing this essential modification process. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin inhibits HMG-CoA reductase, which is involved in cholesterol synthesis. By disrupting cholesterol synthesis, lovastatin might alter peroxisomal lipid composition, which could indirectly compromise Pex7p function in peroxisomal protein import due to changes in peroxisomal membrane fluidity or permeability. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $32.00 $133.00 $449.00 | 5 | |
Ebselen is a mimic of glutathione peroxidase and may influence oxidative stress pathways. Since peroxisomes are involved in the detoxification of reactive oxygen species, ebselen could indirectly inhibit Pex7p by altering the oxidative state within peroxisomes and potentially affecting the import machinery that Pex7p is a part of. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate, like fenofibrate and clofibrate, is a PPAR agonist that can lead to peroxisome proliferation. This proliferation might indirectly inhibit Pex7p by overloading the peroxisomal import capacity, potentially disrupting the import of Pex7p cargo proteins. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B inhibits nuclear export by binding to exportin 1. Although not directly related to peroxisomal function, the altered nuclear export can influence the cellular distribution of transcription factors that regulate genes encoding peroxisomal proteins. This could result in an indirect inhibition of Pex7p by affecting the levels and import of its cargo proteins. | ||||||