Peroxin 7 Activators
Peroxin 7 Activators are a diverse array of chemical compounds that serve to indirectly enhance the functional activity of Peroxin 7 through intricate and specific signaling cascades. Molecules such as Forskolin and Isoproterenol exert their effects by increasing cAMP levels, subsequently activating PKA which is known to phosphorylate a broad range of substrates, including potentially ProteinX. This phosphorylation can lead to a functional increase in Peroxin 7 activity. Similarly, IBMX and Dibutyryl-cAMP raise the intracellular concentration of cAMP, further bolstering PKA activation and thus influencing Peroxin 7 activity. The modulation of intracellular calcium levels by compounds such as A23187 and Ionomycin triggers the activation of calcium-dependent kinases which may directly or indirectly target Peroxin 7 for activation. These ionophores facilitate the influx of calcium ions, thereby activating a cascade of kinases including CaMK which could enhance the activity of Peroxin 7.
In addition to these activators, the adrenergic agonist Epinephrine also contributes to the elevation of cAMP and subsequent PKA activation, potentially leading to an increase in ProteinX function. On another front, pharmacological agents like LY294002, PD98059, U0126, and SB203580 manipulate kinase signaling pathways, such as PI3K/AKT and MAPK/ERK/p38, which are often involved in complex regulatory networks that can influence Peroxin 7 activity. LY294002, by inhibiting PI3K, could lead to the activation of Peroxin 7 through the alleviation of AKT-mediated inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylate cyclase activator that increases intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate proteins involved in the peroxisomal import machinery, potentially enhancing the functional activity of Peroxin 7 in the process of peroxisome biogenesis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to enhanced phosphorylation of peroxisomal membrane proteins, which may include Peroxin 7, thus facilitating its function in peroxisome assembly and maintenance. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate is a peroxisome proliferator-activated receptor (PPAR) agonist. Activation of PPAR can lead to upregulated expression of peroxisomal proteins, indirectly enhancing the activity of Peroxin 7 by increasing the number of peroxisomes. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate is another PPAR agonist with a similar mechanism to Clofibrate, potentially enhancing Peroxin 7 activity by promoting peroxisome proliferation. | ||||||
LTB4 (Leukotriene B4) | 71160-24-2 | sc-201043 | 50 µg | $367.00 | 4 | |
Leukotriene B4 activates peroxisome proliferator-activated receptors, which may lead to an increase in peroxisomal biogenesis and thus enhance the functional activity of Peroxin 7. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone is a PPAR-gamma agonist that might enhance Peroxin 7 activity by promoting the transcription of genes involved in peroxisomal biogenesis and maintenance. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate is a fibric acid derivative that acts as a PPAR-alpha agonist, potentially enhancing Peroxin 7 activity by increasing the number and function of peroxisomes. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
WY-14643 is a PPAR-alpha agonist that may indirectly enhance Peroxin 7 activity by upregulating peroxisomal biogenesis. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $48.00 $167.00 $262.00 $648.00 | 6 | |
GW7647 is a potent PPAR-alpha agonist, which may increase the transcription of peroxisomal proteins and indirectly enhance the function of Peroxin 7. | ||||||