Perlecan Inhibitors
Perlecan, a large heparan sulfate proteoglycan, is a critical component in the extracellular matrix of various tissues and plays a vital role in cell signaling, proliferation, and tissue development. Perlecan inhibitors are substances or compounds that modulate the function or expression of perlecan, affecting its interaction with other cellular components and extracellular molecules. The inhibition of perlecan has been studied primarily in the context of its involvement in various cellular processes, where it acts as a co-receptor for several growth factors and cytokines. The structure of perlecan consists of a core protein with multiple attached glycosaminoglycan chains, which are critical for its biological activities. Inhibitors of perlecan typically target either the core protein or the glycosaminoglycan chains, disrupting the normal function of perlecan and its interaction with other molecules.
The study of perlecan inhibitors is complex due to the multifaceted roles that perlecan plays in the cellular environment. Perlecan is involved in the organization of the extracellular matrix, cell adhesion, and the modulation of cell behavior. It also plays a role in the sequestration and presentation of growth factors to their respective receptors on cell surfaces. By inhibiting perlecan, these processes can be modulated, leading to altered cellular responses. The complexity of perlecan's structure and function means that inhibitors can have a range of effects depending on the specific target and context of inhibition. Understanding the precise mechanisms of action of perlecan inhibitors requires a comprehensive approach, taking into account the various roles of perlecan in different tissues and stages of development. The study of perlecan inhibitors has therefore become an important aspect of understanding cellular processes and the organization of the extracellular matrix.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin may downregulate perlecan expression by inducing oxidative stress and altering cellular signaling pathways, potentially impacting extracellular matrix organization and cell-matrix interactions. | ||||||
Cyclophosphamide | 50-18-0 | sc-361165 sc-361165A sc-361165B sc-361165C | 50 mg 100 mg 500 mg 1 g | $90.00 $146.00 $469.00 $791.00 | 18 | |
Cyclophosphamide could alter cellular functions and reduce perlecan expression by interfering with DNA replication and transcription processes, affecting the stability of the extracellular matrix. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate may decrease perlecan expression by inhibiting dihydrofolate reductase, leading to reduced availability of tetrahydrofolate, a critical cofactor in nucleotide biosynthesis and cellular proliferation. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea can potentially reduce perlecan expression by inhibiting ribonucleotide reductase, disrupting DNA synthesis, and leading to altered cell cycle progression and cellular signaling. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib might decrease perlecan expression through its multi-kinase inhibitory effects, altering various signaling pathways associated with cell proliferation, angiogenesis, and extracellular matrix organization. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to modulate various signaling pathways and transcription factors, potentially leading to a downregulation of perlecan expression and affecting cell adhesion and extracellular matrix stability. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can modulate cellular signaling and has antioxidant properties, which may contribute to its ability to potentially decrease perlecan expression, affecting cellular interactions and tissue homeostasis. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil may inhibit perlecan expression by interfering with DNA and RNA synthesis, disrupting cellular proliferation, and potentially altering the stability of the extracellular matrix. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin can bind to DNA, causing DNA damage and potentially leading to a reduction in perlecan expression, affecting cellular signaling and the integrity of the extracellular matrix. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and disrupts cell division, which could result in altered cellular signaling and a decrease in perlecan expression, impacting cell-matrix interactions and tissue organization. | ||||||