PEPT1 Activators
PEPT1 Activators belong to a chemical class of compounds that are involved in the modulation of the PEPT1 protein, also known as the Proton-Coupled Oligopeptide Transporter 1. PEPT1 is a membrane protein primarily expressed in the epithelial cells of the small intestine and the proximal tubules of the kidney. It plays a pivotal role in the absorption of di- and tripeptides from the intestinal lumen into the enterocytes, which are the absorptive cells of the small intestine. Additionally, PEPT1 is responsible for the reabsorption of peptides from the renal tubular fluid in the kidney. This transporter uses a proton gradient to actively transport di- and tripeptides across the cell membrane, contributing to the uptake of dietary protein breakdown products and the conservation of amino acids in the body. PEPT1 Activators are small molecules designed to interact with PEPT1, influencing its transport activity and, consequently, the absorption of peptides.
The mechanism of action of PEPT1 Activators typically involves binding to specific regions of the PEPT1 transporter, inducing conformational changes that may affect its transport function or interactions with substrate peptides. By modulating PEPT1 activity, these activators impact the rate at which di- and tripeptides are taken up by intestinal and renal epithelial cells. Research into PEPT1 Activators provides valuable insights into the complex regulatory mechanisms governing peptide absorption and amino acid homeostasis. Understanding how these activators interact with PEPT1 contributes to our knowledge of the intricate processes involved in nutrient absorption and renal reabsorption.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gly-Sar | 29816-01-1 | sc-471717 sc-471717A | 1 g 5 g | $112.00 $347.00 | ||
Glycylsarcosine (Gly-Sar) is a dipeptide that acts as a substrate and hence an activator for PEPT1. It increases the transport efficiency of the transporter by binding to its active site, thereby facilitating the study of its transport kinetics. | ||||||
Valacyclovir Hydrochloride | 124832-27-5 | sc-204937 sc-204937A | 50 mg 100 mg | $119.00 $153.00 | ||
Valacyclovir Hydrochloride is known to be actively transported by PEPT1, thereby increasing its oral bioavailability. This prodrug activation is a key example of utilizing PEPT1's transport mechanism for therapeutic purposes. | ||||||
Dabigatran | 211914-51-1 | sc-481166 | 5 mg | $205.00 | 1 | |
Dabigatran etexilate, an oral anticoagulant, is a compound that is effectively transported by PEPT1. This transport enhances the drug's bioavailability, showcasing PEPT1's role in facilitating the absorption of certain pharmaceutical compounds. | ||||||
Cephalexin | 15686-71-2 | sc-211053 sc-211053A sc-211053B sc-211053C | 5 g 100 g 250 g 1 kg | $119.00 $131.00 $235.00 $474.00 | ||
Cephalexin is a compound known to interact with PEPT1. Its molecular structure enables it to bind and be transported by PEPT1, potentially increasing its intestinal absorption. | ||||||
L-Alanyl-L-1-aminoethylphosphonic acid | 60668-24-8 | sc-257647 | 250 mg | $221.00 | ||
L-Alanyl-L-1-aminoethylphosphonic acid utilizes PEPT1 for its transport. This interaction highlights the potential of PEPT1 in aiding the absorption of peptide-like antibiotics. | ||||||
Bestatin | 58970-76-6 | sc-202975 | 10 mg | $131.00 | 19 | |
Bestatin, an inhibitor of aminopeptidases, can also interact with PEPT1, possibly increasing its cellular uptake in PEPT1-expressing tissues. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicinol, has been shown to interact with PEPT1, suggesting a role in its cellular transport. | ||||||
Gly-Pro | 704-15-4 | sc-255188 | 10 g | $443.00 | ||
Gly-Pro, a dipeptide, can be transported by PEPT1, indicating its role as a PEPT1 activator by serving as a substrate. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
1,1-Dimethylbiguanide, Hydrochloride has been studied for its interaction with PEPT1, suggesting potential implications in its intestinal absorption. | ||||||
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $37.00 $47.00 $99.00 $379.00 $733.00 | 2 | |
This dipeptide is a substrate for PEPT1, indicating its role in activating the transporter by enhancing peptide transport. | ||||||