PEPCK-C Activators
Common PEPCK-C Activators include, but are not limited to Dexamethasone CAS 50-02-2, Adenosine 3',5'-cyclic monophosphate CAS 60-92-4, Forskolin CAS 66575-29-9, L-3,3′,5-Triiodothyronine, free acid CAS 6893-02-3 and Resveratrol CAS 501-36-0.
PEPCK-C Activators pertain to a class of molecules that influence the activity of the enzyme phosphoenolpyruvate carboxykinase-cytosolic (PEPCK-C). This enzyme plays a pivotal role in the regulation of gluconeogenesis, a metabolic pathway responsible for the synthesis of glucose from non-carbohydrate precursors in the liver and kidneys. Gluconeogenesis is essential for maintaining blood glucose levels during periods of fasting or low carbohydrate intake, ensuring a steady supply of energy to vital organs like the brain and red blood cells.
PEPCK-C, specifically the cytosolic isoform, is a key enzyme in this process. It catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP), a critical step in gluconeogenesis. PEPCK-C Activators are compounds that modulate the activity of this enzyme, either by enhancing or inhibiting its function. These activators can be natural metabolites, small molecules, or signaling molecules within the cell. By influencing PEPCK-C activity, these molecules indirectly regulate glucose production, which is crucial for maintaining glucose homeostasis in the body. Understanding the mechanisms and molecules involved in PEPCK-C activation is essential for comprehending the intricacies of glucose metabolism and its role in overall metabolic health.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, increases PEPCK-C transcription through the glucocorticoid receptor, promoting gluconeogenesis. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP, by activating protein kinase A (PKA), induces the CREB transcription factor, which promotes PEPCK-C expression, enhancing gluconeogenesis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels by stimulating adenylate cyclase, which can upregulate PEPCK-C expression. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
Thyroid hormones, like T3, can enhance PEPCK-C transcription, influencing gluconeogenesis especially in adaptive thermogenesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is thought to activate SIRT1, which can positively modulate PEPCK-C expression. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR, an AMPK activator, can increase PEPCK-C expression by modulating gluconeogenesis pathways. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine might elevate PEPCK-C expression via AMPK activation, influencing gluconeogenesis. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Typically an AMPK activator, metformin, in specific contexts, might elevate PEPCK-C expression, influencing gluconeogenesis. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Glucocorticoids can enhance PEPCK-C transcription, promoting gluconeogenesis. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2, under certain conditions, might upregulate PEPCK-C expression, influencing gluconeogenesis. | ||||||