PEDF Activators
PEDF Activators, short for Pigment Epithelium-Derived Factor Activators, belong to a specific chemical class of compounds that have garnered significant attention in the field of biomedical research due to their potential role in modulating various cellular processes. Pigment epithelium-derived factor (PEDF) is a multifunctional secreted protein that is naturally present in the human body and is known for its diverse biological activities. PEDF is primarily secreted by the retinal pigment epithelium and is found in various tissues, including the eye, liver, and adipose tissue. Researchers have identified a class of small molecules and peptides that can enhance the expression or activity of PEDF, and these compounds are collectively referred to as PEDF Activators.
PEDF Activators are characterized by their ability to augment the levels or functions of PEDF within biological systems. The mechanism of action of these compounds typically involves either increasing the synthesis and secretion of PEDF by cells or enhancing its binding to specific cellular receptors. As a result, PEDF Activators have the potential to influence a wide range of cellular processes, including angiogenesis (the formation of new blood vessels), inflammation, apoptosis (programmed cell death), and lipid metabolism. These compounds may hold promise in various research contexts, particularly in elucidating the intricate signaling pathways and physiological functions associated with PEDF.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenol found in grapes and red wine, known for its antioxidant properties. It may upregulate PEDF expression via activation of SIRT1, leading to anti-angiogenic and neuroprotective effects. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, the active component of turmeric, has anti-inflammatory and antioxidant properties. It might induce PEDF expression, contributing to its potential anti-angiogenic and neuroprotective activities. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, plays a crucial role in cell growth and differentiation. It has been shown to induce PEDF expression in certain cell types, potentially mediating its anti-angiogenic effects. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, found in broccoli, has antioxidant and anti-inflammatory properties. It may upregulate PEDF via the activation of NRF2, a key regulator of cellular antioxidant response. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, the major catechin in green tea, has antioxidant properties. It might enhance PEDF expression, contributing to its anti-angiogenic and neuroprotective effects. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with antioxidant and anti-inflammatory effects. It could induce PEDF expression, potentially mediating its benefits in inhibiting angiogenesis and protecting neurons. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin is a flavonoid with antioxidant and anti-inflammatory properties. It might increase PEDF expression, playing a role in its anti-angiogenic and neuroprotective effects. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is an essential mineral with antioxidant properties. It could induce PEDF expression, potentially contributing to its role in neuroprotection and inhibition of angiogenesis. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
NAC is an antioxidant and precursor to glutathione. It may upregulate PEDF expression, playing a role in its neuroprotective and anti-inflammatory effects. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a soy-derived isoflavone with antioxidant properties. It could induce PEDF expression, potentially mediating its anti-angiogenic and neuroprotective effects. | ||||||