PDGFRL Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and functions as a potent activator of protein kinase C (PKC). Activation of PKC leads to downstream signaling events that can enhance the activity of PDGFRL, which is implicated in the regulation of cell proliferation and differentiation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can activate PKA, which can phosphorylate substrates that may interact with PDGFRL signaling pathways to enhance its activity in the cell. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate (S1P) is a bioactive lipid that acts through G protein-coupled receptors to activate intracellular signaling cascades, potentially influencing pathways that converge on PDGFRL and enhance its functional activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin receptor activation leads to the activation of PI3K/Akt and MAPK pathways, which can indirectly enhance PDGFRL signaling through pathway convergence and activation of common downstream effectors. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, activating calmodulin-dependent kinases and potentially affecting PDGFRL signaling by enhancing the activity of calcium-sensitive pathways it is involved in. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720 is a sphingosine analog that, upon phosphorylation, can act as an S1P receptor modulator, influencing cellular pathways that could enhance the activity of PDGFRL by affecting the cell's response to growth factors. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can affect multiple signaling pathways including inhibition of NF-κB activation. This can lead to an altered inflammatory response, which may indirectly enhance PDGFRL activity by affecting the cellular context in which it operates. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to activate SIRT1, which can deacetylate proteins involved in the PI3K/Akt pathway. This alteration can lead to the indirect enhancement of PDGFRL activity through modulation of pathway components. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can indirectly enhance PDGFRL signaling by creating a compensatory upregulation of alternate pathways or feedback mechanisms that PDGFRL is a part of, leading to enhanced activity of the protein. | ||||||