PDE7A Activators
PDE7A Activators are a class of chemical compounds that can enhance the functional activity of PDE7A, a cAMP-specific phosphodiesterase. The functional activity of PDE7A is enhanced when the intracellular levels of cAMP are increased. This increase can be achieved by inhibiting other PDE isozymes that degrade cAMP. For instance, IBMX, a non-specific PDE inhibitor, and Rolipram, a PDE4 inhibitor, can increase cAMP levels by inhibiting the degradation of cAMP by other PDE isozymes. The increased cAMP levels indirectly enhance the functional activity of PDE7A as it has more substrate to degrade.
Similarly, PDE5 inhibitors like Sildenafil, Dipyridamole, Tadalafil, and Vardenafil increase cGMP levels. The elevated cGMP levels can cause a compensatory increase in cAMP degradation, indirectly enhancing PDE7A activity. Zardaverine, Milrinone, Cilostazol, and Enoximone are PDE3 inhibitors that increase cAMP levels by inhibiting PDE3, another cAMP-degrading isozyme. The increased cAMP levels indirectly enhance the functional activity of PDE7A. Vinpocetine, a PDE1 inhibitor, also enhances PDE7A activity by increasing cAMP levels. Papaverine, a non-specific PDE inhibitor, promotes the accumulation of cAMP, providing more substrate for PDE7A to degrade, thereby enhancing its activity.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific PDE inhibitor that inhibits most PDE isozymes. It can enhance PDE7A activity indirectly by promoting the accumulation of cAMP, which PDE7A works to degrade. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective PDE4 inhibitor. By inhibiting PDE4, it increases cAMP levels, indirectly enhancing the functional activity of PDE7A. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a dual PDE3/4 inhibitor. By inhibiting PDE3 and PDE4, it increases cAMP levels, indirectly enhancing the functional activity of PDE7A. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $162.00 $683.00 | 7 | |
Milrinone is a PDE3 inhibitor. By inhibiting PDE3, it increases cAMP levels, indirectly enhancing the functional activity of PDE7A. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol is a PDE3 inhibitor. By inhibiting PDE3, it increases cAMP levels, indirectly enhancing the functional activity of PDE7A. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $30.00 $100.00 | 1 | |
Dipyridamole is a PDE5 inhibitor. By inhibiting PDE5, it increases cGMP levels, indirectly enhancing the functional activity of PDE7A through a compensatory increase in cAMP degradation. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $176.00 | 13 | |
Tadalafil is a PDE5 inhibitor. By inhibiting PDE5, it increases cGMP levels, indirectly enhancing PDE7A activity by causing a compensatory increase in cAMP degradation. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $516.00 $720.00 $16326.00 | 7 | |
Vardenafil is a PDE5 inhibitor. By inhibiting PDE5, it increases cGMP levels, indirectly enhancing PDE7A activity by causing a compensatory increase in cAMP degradation. | ||||||
Papaverine | 58-74-2 | sc-279951 sc-279951A sc-279951B | 10 mg 50 mg 100 mg | $153.00 $265.00 $459.00 | ||
Papaverine is a nonspecific PDE inhibitor. It can enhance PDE7A activity indirectly by promoting the accumulation of cAMP, which PDE7A works to degrade. | ||||||
Enoximone | 77671-31-9 | sc-252775 sc-252775A | 10 mg 50 mg | $181.00 $728.00 | 1 | |
Enoximone is a PDE3 inhibitor. By inhibiting PDE3, it increases cAMP levels, indirectly enhancing the functional activity of PDE7A. | ||||||