PDE Inhibitors
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Items 11 to 20 of 84 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $516.00 $720.00 $16326.00 | 7 | |
Vardenafil acts as a phosphodiesterase (PDE) inhibitor, characterized by its ability to stabilize the enzyme's conformation through specific hydrogen bonding interactions. This compound demonstrates a unique selectivity for PDE5, leading to a significant modulation of cyclic GMP levels. Its kinetic behavior showcases a non-competitive inhibition pattern, impacting the enzyme's catalytic efficiency. Additionally, Vardenafil's lipophilic nature enhances membrane permeability, affecting intracellular signaling pathways. | ||||||
Papaverine hydrochloride | 61-25-6 | sc-202273 | 5 g | $51.00 | 4 | |
Papaverine hydrochloride functions as a phosphodiesterase (PDE) inhibitor, exhibiting a distinctive ability to interact with the enzyme's active site through hydrophobic and electrostatic interactions. This compound selectively influences cyclic AMP levels, showcasing a reversible inhibition mechanism that alters the enzyme's turnover rate. Its amphiphilic characteristics facilitate interactions with lipid membranes, potentially influencing cellular signaling dynamics and modulating various biochemical pathways. | ||||||
5′-Deoxy-5′-methylthioadenosine | 2457-80-9 | sc-202427 | 50 mg | $120.00 | 1 | |
5′-Deoxy-5′-methylthioadenosine acts as a phosphodiesterase (PDE) modulator, characterized by its unique ability to disrupt the enzyme's catalytic activity through specific binding interactions. This compound exhibits a preference for certain isoforms of PDE, leading to selective modulation of cyclic nucleotide signaling. Its structural features allow for enhanced stability in biological systems, influencing reaction kinetics and promoting distinct regulatory pathways within cellular environments. | ||||||
Quercetin Dihydrate | 6151-25-3 | sc-203225 sc-203225A | 5 g 25 g | $35.00 $60.00 | 1 | |
Quercetin Dihydrate functions as a phosphodiesterase (PDE) inhibitor, showcasing its capacity to interact with the enzyme's active site through hydrogen bonding and hydrophobic interactions. This compound selectively influences cyclic nucleotide levels, modulating intracellular signaling pathways. Its unique flavonoid structure contributes to its stability and solubility, affecting reaction kinetics and enhancing its potential to regulate various cellular processes. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin acts as a phosphodiesterase (PDE) inhibitor, exhibiting a distinctive ability to disrupt enzyme activity through specific interactions with the enzyme's binding sites. Its unique flavonoid backbone allows for effective stacking interactions with nucleobases, influencing the stability of cyclic nucleotides. This modulation of cyclic nucleotide degradation alters cellular signaling dynamics, showcasing its role in fine-tuning various biochemical pathways and enhancing cellular responses. | ||||||
Enniatin B | 917-13-5 | sc-202150 | 1 mg | $300.00 | 4 | |
Enniatin B functions as a phosphodiesterase (PDE) inhibitor, characterized by its unique cyclic structure that facilitates strong interactions with the enzyme's active site. This compound exhibits selective binding, which alters the conformational dynamics of PDE, impacting substrate affinity and reaction kinetics. Its ability to stabilize cyclic nucleotides leads to prolonged signaling effects, thereby influencing various cellular processes and regulatory mechanisms. | ||||||
Ophiobolin A | 4611-05-6 | sc-202266 sc-202266A sc-202266B | 100 µg 1 mg 5 mg | $43.00 $245.00 $714.00 | 7 | |
Ophiobolin A acts as a phosphodiesterase (PDE) inhibitor, distinguished by its complex molecular architecture that enables specific interactions with the enzyme's catalytic domain. This compound disrupts the normal hydrolysis of cyclic nucleotides, resulting in altered enzymatic activity and modulation of intracellular signaling pathways. Its unique stereochemistry contributes to its binding affinity, influencing the kinetics of substrate turnover and cellular responses. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $30.00 $100.00 | 1 | |
Dipyridamole functions as a phosphodiesterase (PDE) inhibitor, characterized by its dual-ring structure that facilitates selective binding to the enzyme's active site. This interaction stabilizes the enzyme-substrate complex, leading to a decrease in the breakdown of cyclic nucleotides. The compound's unique electronic properties enhance its affinity for the PDE, affecting the rate of reaction and influencing downstream signaling cascades within cellular environments. | ||||||
MDL-12,330A • HCl | 40297-09-4 | sc-201574 sc-201574A | 5 mg 25 mg | $71.00 $279.00 | 12 | |
MDL-12,330A • HCl acts as a potent phosphodiesterase (PDE) inhibitor, distinguished by its unique structural conformation that promotes specific interactions with the enzyme's binding site. This compound exhibits a remarkable ability to modulate enzyme kinetics, effectively altering the hydrolysis of cyclic nucleotides. Its distinct steric and electronic characteristics contribute to a selective inhibition profile, impacting various intracellular signaling pathways and regulatory mechanisms. | ||||||
Theobromine | 83-67-0 | sc-203296 sc-203296A | 25 g 100 g | $41.00 $87.00 | ||
Theobromine functions as a phosphodiesterase (PDE) inhibitor, characterized by its ability to selectively bind to the enzyme's active site. This interaction stabilizes the enzyme-substrate complex, leading to a decrease in the breakdown of cyclic nucleotides. Theobromine's unique molecular structure enhances its affinity for specific PDE isoforms, influencing reaction rates and promoting prolonged signaling cascades. Its distinct hydrophobic regions facilitate interactions with lipid membranes, further modulating cellular responses. | ||||||