Molecular structure of Enniatin B, CAS Number: 917-13-5
Enniatin B (CAS 917-13-5)
See product citations (4)
Alternate Names:
3-N-Methylvaline Enniatin; (3S,6R,9S,12R,15S,18R)-4,10,16-trimethyl-3,6,9,12,15, 18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8, 11,14,17-hexone
Application:
Enniatin B is an ionophore antibiotic that inhibits ACAT and PDE
CAS Number:
917-13-5
Purity:
≥95%
Molecular Weight:
639.82
Molecular Formula:
C33H57N3O9
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Enniatin B is an ionophore antibiotic and fungal metabolite generated by multiple Fusarium strains. Studies indicate that Enniatin B has cytotoxic activity in vitro, but no genotoxic activity. Enniatin B may act to inhibit the Pdr5p ABC transporter in Saccharomyces cerevisiae, as well as acyl-CoA-cholesterol acyltransferase (ACAT). Additionally, joint studies of valinomycin (sc-200991) and enniatin B have demonstrated that they can bind to calmodulin (CaM) and inhibit the activity of 3′,5′-cyclic nucleotide phosphodiesterase (PDE). It is believed that enniatin B possess anticancer properties.
Enniatin B (CAS 917-13-5) References
- Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. | Hiraga, K., et al. 2005. Biochem Biophys Res Commun. 328: 1119-25. PMID: 15707993
- Interaction of cyclic peptides and depsipeptides with calmodulin. | Mereish, KA., et al. 1990. Pept Res. 3: 233-7. PMID: 1724618
- Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. | Dornetshuber, R., et al. 2007. Chem Res Toxicol. 20: 465-73. PMID: 17326668
- The Fusarium toxin enniatin B exerts no genotoxic activity, but pronounced cytotoxicity in vitro. | Behm, C., et al. 2009. Mol Nutr Food Res. 53: 423-30. PMID: 19360736
- Interaction effects of enniatin B, deoxinivalenol and alternariol in Caco-2 cells. | Fernández-Blanco, C., et al. 2016. Toxicol Lett. 241: 38-48. PMID: 26581633
- A Review of the Mycotoxin Enniatin B. | Prosperini, A., et al. 2017. Front Public Health. 5: 304. PMID: 29201864
- Beauvericin and enniatin B effects on a human lymphoblastoid Jurkat T-cell model. | Manyes, L., et al. 2018. Food Chem Toxicol. 115: 127-135. PMID: 29530640
- Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells. | Krug, I., et al. 2018. PLoS One. 13: e0197406. PMID: 29768483
- Enniatin B induces expression changes in the electron transport chain pathway related genes in lymphoblastic T-cell line. | Alonso-Garrido, M., et al. 2018. Food Chem Toxicol. 121: 437-443. PMID: 30227181
- Enniatin B1-induced lysosomal membrane permeabilization in mouse embryonic fibroblasts. | Oliveira, CAF., et al. 2020. Mycotoxin Res. 36: 23-30. PMID: 31264166
- Enniatin B induces dosage-related apoptosis or necrosis in mouse blastocysts leading to deleterious effects on embryo development. | Huang, CH., et al. 2022. Drug Chem Toxicol. 45: 1449-1460. PMID: 33106064
- Study of locomotion response and development in zebrafish (Danio rerio) embryos and larvae exposed to enniatin A, enniatin B, and beauvericin. | Juan-García, A., et al. 2021. Sci Total Environ. 777: 146075. PMID: 33677298
- Enniatin B and Deoxynivalenol Activity on Bread Wheat and on Fusarium Species Development. | Ederli, L., et al. 2021. Toxins (Basel). 13: PMID: 34679021
- Beauvericin (BEA) and enniatin B (ENNB)-induced impairment of mitochondria and lysosomes - Potential sources of intracellular reactive iron triggering ferroptosis in Atlantic salmon primary hepatocytes. | Søderstrøm, S., et al. 2022. Food Chem Toxicol. 161: 112819. PMID: 35038498
- Enniatin B and valinomycin as ion carriers: an empirical force field analysis. | Lifson, S., et al. 1984. J Biomol Struct Dyn. 2: 641-61. PMID: 6400917
Inhibitor of:
ACAT, and PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Enniatin B, 1 mg | sc-202150 | 1 mg | $300.00 |