Date published: 2025-11-26

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PDE Activators

Santa Cruz Biotechnology now offers a broad range of PDE Activators for use in various applications. PDE Activators are vital in the study of phosphodiesterase (PDE) enzymes, which play crucial roles in cellular signaling by regulating the levels of cyclic nucleotides, such as cAMP and cGMP. These activators enhance PDE activity, leading to the breakdown of cyclic nucleotides and subsequent modulation of signal transduction pathways. By employing PDE Activators, researchers can investigate the fine-tuning of intracellular signaling cascades, which are fundamental to numerous physiological processes including cell growth, differentiation, and metabolism. The ability to modulate PDE activity with specific activators allows scientists to explore the regulatory mechanisms governing cyclic nucleotide signaling in various cellular contexts. This has significant implications for understanding the dynamics of signal transduction and how alterations in these pathways contribute to cellular function and dysfunction. PDE Activators are also utilized to study the cross-talk between different signaling pathways, providing insights into the integration and coordination of cellular responses to external stimuli. Additionally, these activators support research in the fields of neurobiology, cardiovascular biology, and endocrinology, where cyclic nucleotide signaling plays a pivotal role in maintaining cellular homeostasis and function. The use of PDE Activators facilitates the development of new experimental approaches and the identification of novel regulatory mechanisms, thereby advancing our understanding of cellular signaling networks. View detailed information on our available PDE Activators by clicking on the product name.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ro 20-1724

29925-17-5sc-200709
sc-200709A
sc-200709B
100 mg
1 g
5 g
$85.00
$418.00
$1543.00
17
(1)

Ro 20-1724 is a selective phosphodiesterase (PDE) inhibitor that modulates intracellular signaling pathways by stabilizing cyclic nucleotide levels. Its unique binding affinity to the PDE active site enhances the accumulation of cyclic AMP, leading to altered cellular responses. The compound's structural features promote specific interactions with the enzyme, influencing reaction kinetics and selectivity. This selectivity is crucial for dissecting complex biochemical networks and understanding cellular regulation.

Calmodulin (human), (recombinant)

73298-54-1sc-471287
1 mg
$232.00
(0)

Calmodulin (human, recombinant) is a calcium-binding protein that plays a pivotal role in cellular signaling by interacting with various target proteins. Its unique ability to undergo conformational changes upon calcium binding allows it to modulate enzyme activities, including phosphodiesterases. This dynamic interaction influences cyclic nucleotide metabolism, impacting downstream signaling pathways. The protein's versatility in binding and activating multiple targets underscores its significance in regulating diverse physiological processes.

Ibudilast

50847-11-5sc-203080
10 mg
$214.00
1
(1)

Ibudilast functions as a phosphodiesterase (PDE) inhibitor, exhibiting a unique ability to modulate intracellular signaling by selectively interacting with cyclic nucleotide pathways. Its structure allows for specific binding to the active sites of PDE enzymes, altering their kinetics and enhancing the accumulation of cyclic AMP and cyclic GMP. This modulation can lead to intricate changes in cellular responses, influencing various biochemical cascades and regulatory mechanisms within the cell.