PCDHGB5 Inhibitors
PCDHGB5 inhibitors represent a distinctive chemical class designed to selectively modulate the activity of the protocadherin gamma subfamily B member 5 (PCDHGB5) protein. Protocadherins are a family of cell-adhesion molecules involved in various developmental and physiological processes, particularly in the nervous system. PCDHGB5, as a member of this subfamily, contributes to cellular recognition and communication through its involvement in cell adhesion and signal transduction. Inhibitors targeting PCDHGB5 operate by interfering with its normal functions, disrupting the intricate molecular interactions and signaling pathways in which PCDHGB5 is engaged. This interference may lead to alterations in cell adhesion patterns and impact cellular communication governed by PCDHGB5.
The mechanism of action of PCDHGB5 inhibitors involves their ability to selectively bind to PCDHGB5, modulating its activity and potentially influencing downstream cellular processes. By perturbing the precise molecular events in which PCDHGB5 participates, these inhibitors serve as valuable tools for researchers exploring the specific functions of protocadherins within the broader landscape of cellular biology, particularly in the context of neural development and cell communication. The study of PCDHGB5 inhibitors contributes to a deeper understanding of the regulatory mechanisms that govern cell adhesion and communication, shedding light on the intricate molecular processes underlying the normal functioning of the nervous system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor that may demethylate gene promoters, potentially changing PCDHGB5 expression. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 is a selective inhibitor of p300, a histone acetyltransferase, which could alter histone acetylation and affect gene expression. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
Chaetocin is known to inhibit histone methyltransferase, particularly SUV39H1, which may impact chromatin structure and gene expression. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
DZNep is an inhibitor of histone methyltransferase EZH2 and can affect global and gene-specific methylation levels. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid is an HDAC inhibitor that could change the chromatin structure, potentially influencing the expression of PCDHGB5. | ||||||
Apicidin | 183506-66-3 | sc-202061 sc-202061A | 1 mg 5 mg | $108.00 $336.00 | 9 | |
Apicidin is a cyclic peptide with HDAC inhibitory activity, which might affect gene expression through histone acetylation changes. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 (Entinostat) is a benzamide HDAC inhibitor that can modify chromatin structure and potentially alter gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is an HDAC inhibitor that may impact the acetylation state of histones and consequently the transcription of genes like PCDHGB5. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib is a PARP inhibitor, and while its primary action is on DNA repair, it may also have indirect effects on gene expression. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 disrupts the interaction between p53 and MDM2, potentially leading to changes in p53-regulated gene expression. | ||||||