PCDHGA11 Activators
PCDHGA11 Activators are a collection of chemical compounds that enhance the functional activity of PCDHGA11 through distinct and specific signaling pathways. Forskolin, through the elevation of intracellular cAMP levels, activates protein kinase A, leading to phosphorylation events that may enhance PCDHGA11's role in cellular adhesion. Similarly, Genistein's inhibition of tyrosine kinases could potentiate PCDHGA11 signaling by diminishing competitive or inhibitory tyrosine kinase signaling. Sphingosine-1-phosphate and Thapsigargin both enhance cellular processes that PCDHGA11 is known to influence; the former through sphingolipid signaling and the latter via calcium signaling, both converging on actin cytoskeletal dynamics critical for cell-cell adhesion. PMA, as a PKC activator, and EGCG, through its inhibitory effect on multiple kinases, have the potential to phosphorylate and inactivate proteins that impede PCDHGA11-related pathways, thereby reinforcing PCDHGA11's adhesive and signaling functions.
Moreover, the PI3K pathway, which can be modulated by inhibitors such as LY294002 and Wortmannin, plays a pivotal role in cellular signaling, and its downregulation might lead to an upsurge in PCDHGA11-mediated activities by alleviating competitive inhibitory effects. U0126 and SB203580, by targeting and inhibiting MEK1/2 and p38 MAP kinase respectively, may shift the signaling balance to enhance PCDHGA11's role in cell adhesion mechanisms. Lastly, A23187's elevation of intracellular calcium levels and Staurosporine's broad-spectrum kinase inhibition may selectively activate PCDHGA11's signaling pathways, emphasizing its role in cellular communication and adhesion. Each of these activators, through their unique interactions with cellular signaling pathways, serves to enhance the functional activity of PCDHGA11, culminating in a concerted effect that supports its specific cellular roles.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, which increases the production of cyclic AMP (cAMP) in cells. Elevated cAMP levels lead to the activation of protein kinase A (PKA), which can then phosphorylate various substrates that may include proteins associated with the PCDHGA11-related signaling pathways, thereby enhancing PCDHGA11's functional activity in cell-cell adhesion. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can reduce the activity of competing tyrosine kinase pathways, thus potentially enhancing the signaling pathways in which PCDHGA11 is involved, as it may decrease the phosphorylation of proteins that negatively regulate PCDHGA11 function. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P acts on its specific G-protein-coupled receptors to initiate signaling cascades that can lead to actin cytoskeletal rearrangements. Such rearrangements can influence the functional activity of PCDHGA11, by promoting cellular processes that are conducive to PCDHGA11's role in cell adhesion. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin elevates intracellular calcium levels by blocking the calcium ATPase of the endoplasmic reticulum. Increased calcium can activate calcium-dependent signaling pathways, which could enhance the signaling pathways that promote PCDHGA11-mediated cell adhesion. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate substrates that influence PCDHGA11’s functional activity. This can enhance PCDHGA11-mediated signaling by modulating the cytoskeletal organization and cell adhesion. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits multiple kinases, potentially reducing the phosphorylation of proteins that negatively regulate the signaling pathways in which PCDHGA11 is involved, thereby enhancing PCDHGA11's functional activity in cell adhesion and communication. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can modulate the PI3K/Akt pathway. By inhibiting this pathway, LY294002 might enhance PCDHGA11-related signaling by reducing competitive signaling that negatively affects PCDHGA11’s functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that functions similarly to LY294002. It could enhance PCDHGA11 signaling by attenuating PI3K/Akt pathway activity, which might otherwise downregulate PCDHGA11-associated functions. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 specifically inhibits p38 MAP kinase, which may result in the enhancement of PCDHGA11 signaling pathways by decreasing the phosphorylation of proteins that negatively regulate PCDHGA11's functions. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, leading to the activation of calcium-dependent signaling pathways. This can enhance PCDHGA11's role in cellular processes such as adhesion and communication. | ||||||