Date published: 2025-12-21

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PCDHAC2_Pcdhac2 Inhibitors

PCDHAC2_Pcdhac2 inhibitors belong to a distinct chemical class designed to selectively modulate the activity of the protocadherin alpha subfamily C member 2 (PCDHAC2_Pcdhac2) protein. Protocadherins, a family of cell adhesion molecules, play pivotal roles in mediating cellular interactions, particularly in the nervous system, where they contribute to neural development, synaptic connectivity, and the establishment of neural circuits. PCDHAC2_Pcdhac2, as a member of the alpha subfamily, is specifically expressed in neural tissues, underscoring its importance in governing complex cellular processes. The inhibitors developed for PCDHAC2_Pcdhac2 possess a unique chemical structure, enabling them to interact selectively with specific binding sites on the PCDHAC2_Pcdhac2 protein, thereby influencing its molecular activities at the cellular level.

The mechanism of action of PCDHAC2_Pcdhac2 inhibitors involves disrupting the normal functioning of the PCDHAC2_Pcdhac2 protein, potentially impacting cellular processes such as neural cell adhesion, guidance, and synapse formation. The precise design of these inhibitors ensures a high level of specificity, minimizing unintended effects on other closely related protocadherins. As researchers delve into the intricacies of neural development and cellular adhesion, PCDHAC2_Pcdhac2 inhibitors serve as invaluable tools, allowing for the exploration of the intricate signaling cascades and molecular interactions involving PCDHAC2_Pcdhac2. The study of this chemical class contributes to a deeper understanding of the role played by PCDHAC2_Pcdhac2 in cellular physiology, offering insights into its potential functions within the complex networks that shape neural circuits.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

RG 108

48208-26-0sc-204235
sc-204235A
10 mg
50 mg
$128.00
$505.00
2
(1)

RG108 is a DNA methyltransferase inhibitor that can demethylate promoters and enhance gene expression but also has the potential to indirectly suppress gene expression by altering the epigenetic state of a cell.

Disulfiram

97-77-8sc-205654
sc-205654A
50 g
100 g
$52.00
$87.00
7
(1)

Disulfiram can chelate copper and has been shown to inhibit the proteasome, which might lead to reduced expression of certain genes indirectly through altered degradation pathways.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein is an isoflavone that acts as a tyrosine kinase inhibitor and has been shown to affect DNA methylation and histone acetylation, potentially influencing PCDHA@ expression.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$30.00
$46.00
$82.00
$218.00
19
(3)

Sodium butyrate is a histone deacetylase inhibitor that can cause hyperacetylation of histones, leading to changes in gene expression, including potentially inhibiting PCDHA@.

Parthenolide

20554-84-1sc-3523
sc-3523A
50 mg
250 mg
$79.00
$300.00
32
(2)

Parthenolide can inhibit NF-κB, a transcription factor that regulates many genes; its modulation could potentially influence PCDHA@ expression indirectly.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol has been shown to have histone deacetylase inhibitory activity, which could change the expression profile of a wide range of genes, including PCDHA@.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin is known to affect a variety of signaling pathways and may alter gene expression indirectly by modulating transcription factors and epigenetic marks.

Chloroquine

54-05-7sc-507304
250 mg
$68.00
2
(0)

Chloroquine can elevate lysosomal pH and affect epigenetic regulation and autophagy, potentially leading to changes in gene expression.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

EGCG is the main catechin in green tea and has been implicated in DNA methylation changes, which could impact the expression of genes like PCDHA@.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$130.00
$270.00
37
(2)

SAHA is a well-known histone deacetylase inhibitor and may affect the acetylation status of histones near the PCDHA@ gene, altering its expression.