PCDHAC2_Pcdhac2 inhibitors belong to a distinct chemical class designed to selectively modulate the activity of the protocadherin alpha subfamily C member 2 (PCDHAC2_Pcdhac2) protein. Protocadherins, a family of cell adhesion molecules, play pivotal roles in mediating cellular interactions, particularly in the nervous system, where they contribute to neural development, synaptic connectivity, and the establishment of neural circuits. PCDHAC2_Pcdhac2, as a member of the alpha subfamily, is specifically expressed in neural tissues, underscoring its importance in governing complex cellular processes. The inhibitors developed for PCDHAC2_Pcdhac2 possess a unique chemical structure, enabling them to interact selectively with specific binding sites on the PCDHAC2_Pcdhac2 protein, thereby influencing its molecular activities at the cellular level.
The mechanism of action of PCDHAC2_Pcdhac2 inhibitors involves disrupting the normal functioning of the PCDHAC2_Pcdhac2 protein, potentially impacting cellular processes such as neural cell adhesion, guidance, and synapse formation. The precise design of these inhibitors ensures a high level of specificity, minimizing unintended effects on other closely related protocadherins. As researchers delve into the intricacies of neural development and cellular adhesion, PCDHAC2_Pcdhac2 inhibitors serve as invaluable tools, allowing for the exploration of the intricate signaling cascades and molecular interactions involving PCDHAC2_Pcdhac2. The study of this chemical class contributes to a deeper understanding of the role played by PCDHAC2_Pcdhac2 in cellular physiology, offering insights into its potential functions within the complex networks that shape neural circuits.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor that can demethylate promoters and enhance gene expression but also has the potential to indirectly suppress gene expression by altering the epigenetic state of a cell. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can chelate copper and has been shown to inhibit the proteasome, which might lead to reduced expression of certain genes indirectly through altered degradation pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone that acts as a tyrosine kinase inhibitor and has been shown to affect DNA methylation and histone acetylation, potentially influencing PCDHA@ expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can cause hyperacetylation of histones, leading to changes in gene expression, including potentially inhibiting PCDHA@. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide can inhibit NF-κB, a transcription factor that regulates many genes; its modulation could potentially influence PCDHA@ expression indirectly. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to have histone deacetylase inhibitory activity, which could change the expression profile of a wide range of genes, including PCDHA@. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known to affect a variety of signaling pathways and may alter gene expression indirectly by modulating transcription factors and epigenetic marks. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can elevate lysosomal pH and affect epigenetic regulation and autophagy, potentially leading to changes in gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is the main catechin in green tea and has been implicated in DNA methylation changes, which could impact the expression of genes like PCDHA@. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is a well-known histone deacetylase inhibitor and may affect the acetylation status of histones near the PCDHA@ gene, altering its expression. | ||||||