PBXIP1 Inhibitors
PBXIP1 inhibitors are a distinct class of chemical compounds that specifically target the protein PBXIP1, known as pre-B-cell leukemia homeobox interacting protein 1. PBXIP1 plays a significant role in the regulation of gene expression by interacting with PBX transcription factors, which are crucial for developmental processes and cellular differentiation. By binding to PBX proteins, PBXIP1 can modulate their localization and activity within the nucleus, influencing the transcription of various genes. Inhibitors of PBXIP1 are designed to disrupt these interactions, thereby providing a means to study the functional consequences of PBXIP1 activity on gene regulation and cellular pathways.
The development of PBXIP1 inhibitors involves advanced techniques such as computational modeling, molecular docking, and high-throughput screening to identify compounds that can effectively bind to PBXIP1. These inhibitors may be small organic molecules, peptides, or other biologically active substances crafted to interact with specific domains of the PBXIP1 protein. By inhibiting PBXIP1, researchers can observe changes in gene expression patterns and cellular functions, gaining insights into the mechanisms by which PBXIP1 influences biological processes. The study of these inhibitors contributes to a deeper understanding of protein-protein interactions, transcriptional regulation, and the complex networks that govern cellular behavior.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine inhibits protein kinases which could lead to the inhibition of phosphorylation-dependent interactions involving Pre-B-cell leukemia transcription factor-interacting protein 1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 inhibits PI3K, which is upstream in signaling pathways where Pre-B-cell leukemia transcription factor-interacting protein 1 might be implicated, leading to its inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, potentially influencing pathways that control the function of Pre-B-cell leukemia transcription factor-interacting protein 1, therefore inhibiting its activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases which can alter chromatin structure and gene expression patterns, possibly inhibiting the function of Pre-B-cell leukemia transcription factor-interacting protein 1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits MEK, which may lead to reduced ERK pathway activity, a pathway that could regulate Pre-B-cell leukemia transcription factor-interacting protein 1 function, leading to its inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which could lead to inhibition of AP-1 related transcription factors that might interact with Pre-B-cell leukemia transcription factor-interacting protein 1, inhibiting its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 selectively inhibits p38 MAP kinase, potentially diminishing the activity of pathways that involve Pre-B-cell leukemia transcription factor-interacting protein 1, leading to its inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 selectively inhibits MEK, which may decrease ERK pathway activity that could be implicated in regulating Pre-B-cell leukemia transcription factor-interacting protein 1, inhibiting its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor, potentially reducing activity in pathways that involve Pre-B-cell leukemia transcription factor-interacting protein 1, thus inhibiting its function. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a broad spectrum tyrosine kinase inhibitor, which could inhibit kinases that phosphorylate proteins interacting with Pre-B-cell leukemia transcription factor-interacting protein 1, thus inhibiting its function. | ||||||