Pax-4 Activators
Pax4 activators are a class of chemical compounds that enhance the functional activity of Pax4 through their roles in the cAMP-PKA pathway. The primary mechanism through which these activators function is by increasing intracellular cAMP levels, which in turn activates PKA. PKA then enhances the functional activity of Pax4 through phosphorylation. The Pax4 activators that follow this mechanism include Exendin-4, Forskolin, IBMX, Rolipram, GLP-1, PTH (1-34), Liraglutide, Dibutyryl-cAMP, 8-Br-cAMP, and Sp-cAMPS. Each of these compounds, through their specific actions on the cAMP-PKA pathway, provide different mechanisms for enhancing the functional activity of Pax4.
Additionally, there are Pax4 activators that function by influencing the cAMP-PKA pathway in a more complex manner. These compounds include H-89 and SQ22536, which are generally known as inhibitors of PKA and adenylate cyclase respectively. However, under certain conditions, these compounds can paradoxically enhance the functional activity of Pax4. This is achieved by promoting the phosphorylation of Pax4, despite the general inhibitory effects these compounds have on the cAMP-PKA pathway. This demonstrates the dynamic nature of cellular signaling pathways and how different compounds can influence the same pathway in diverse ways to achieve a similar outcome – in this case, the enhanced functional activity of Pax4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Exendin-4 | 141758-74-9 | sc-474611 sc-474611A | 500 µg 1 mg | $143.00 $194.00 | 1 | |
Exendin-4 is a GLP-1 receptor agonist. Activation of the GLP-1 receptor can stimulate cAMP production, which subsequently activates protein kinase A (PKA). PKA is known to phosphorylate Pax4, enhancing its functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylate cyclase activator which increases intracellular cAMP levels. The increased cAMP activates PKA, which phosphorylates and enhances the functional activity of Pax4. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, leading to increased intracellular cAMP levels. This activation of PKA, due to elevated cAMP, results in the phosphorylation and enhanced functional activity of Pax4. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 inhibitor, which increases intracellular cAMP levels. The elevated cAMP activates PKA, leading to the phosphorylation and enhanced functional activity of Pax4. | ||||||
Parathyroid hormone fragment (1-34) | 52232-67-4 | sc-487943 | 100 µg | $185.00 | ||
PTH (1-34) is a parathyroid hormone receptor agonist. It increases intracellular cAMP, which activates PKA, resulting in the phosphorylation and functional activation of Pax4. | ||||||
Liraglutide | 204656-20-2 | sc-507404 | 1 mg | $220.00 | ||
Liraglutide is a GLP-1 receptor agonist. It increases cAMP production, which activates PKA, leading to the phosphorylation and enhanced functional activity of Pax4. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. The activated PKA phosphorylates Pax4, enhancing its functional activity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP is another cell-permeable cAMP analog that activates PKA. The activated PKA can then phosphorylate and enhance the functional activity of Pax4. | ||||||
Sp-cAMPS | 93602-66-5 | sc-201571 | 1 mg | $95.00 | 3 | |
Sp-cAMPS is a cell-permeable, phosphodiesterase-resistant cAMP analog that activates PKA. The activated PKA phosphorylates Pax4, enhancing its functional activity. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is a potent and selective inhibitor of PKA. Although it generally inhibits PKA, it can paradoxically enhance the functional activity of Pax4 by promoting its phosphorylation under certain conditions. | ||||||