PATE2 Inhibitors
PATE2 inhibitors are a specialized group of chemical compounds designed to selectively target and inhibit the PATE2 protein. PATE2, standing for Prostate And Testis Expressed 2, is a member of a gene family predominantly expressed in male reproductive tissues such as the prostate and testis. This protein is believed to play a significant role in reproductive biology, possibly influencing sperm development and function. By inhibiting PATE2, researchers aim to disrupt its normal activity, allowing them to study its specific contributions to cellular processes and to understand the molecular mechanisms in which it is involved.
The development of PATE2 inhibitors involves advanced techniques in chemical synthesis and molecular biology. Researchers employ methods like rational drug design and computational modeling to create molecules that can bind effectively to PATE2's active sites or alter its conformation. High-throughput screening of chemical libraries may also be utilized to identify potential inhibitory compounds. These inhibitors can vary widely in their chemical structures, including small organic molecules and peptide-based compounds, each engineered to interfere with PATE2 in a distinct manner. Utilizing these inhibitors in experimental settings provides valuable insights into PATE2's role within cells and contributes to a deeper understanding of the complex regulatory networks in reproductive tissues. This research enhances the broader scientific knowledge of reproductive biology and molecular signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A could downregulate PATE2 by altering histone acetylation, leading to a less transcriptionally active chromatin state around the gene′s regulatory regions. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound may decrease PATE2 expression by inducing hypomethylation of DNA within the gene′s promoter area, thereby silencing its transcriptional activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid is likely to decrease PATE2 expression by inhibiting histone deacetylases, which results in tighter chromatin that is less accessible for transcription factors. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275may specifically inhibit class I histone deacetylases, leading to decreased transcription of genes like PATE2 by making the chromatin structure less permissive for transcription. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin could inhibit PATE2 by robustly inhibiting histone deacetylase activity, resulting in silenced gene expression through condensed chromatin. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
By inhibiting a broad spectrum of histone deacetylases, Panobinostat likely leads to decreased expression of PATE2 by promoting a condensed chromatin environment. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat may decrease the expression of PATE2 by inhibiting several isozymes of histone deacetylase, resulting in a transcriptionally inactive chromatin state at the gene locus. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is expected to downregulate PATE2 expression by inhibiting HDAC enzymes, which leads to a less open chromatin configuration and reduced transcriptional activity. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $62.00 $250.00 $1196.00 | ||
Chidamide could reduce PATE2 expression through its histone deacetylase inhibitory action, leading to more tightly packed chromatin that discourages transcription. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid might reduce transcription of PATE2 by inhibiting histone deacetylases, thereby promoting chromatin structures that are unfavorable for gene expression. | ||||||