PARD3B Activators
Partitioning defective 3 homolog B (PARD3B) activators are a class of compounds that enhance the functional activity of PARD3B through their influence on associated pathways and processes. PARD3B is a key component involved in cellular polarity and tight junction formation, processes that are critical for the maintenance of tissue architecture and function. These activators work by either directly or indirectly influencing the signaling pathways in which PARD3B is involved, thereby enhancing its functional activity. For instance, compounds such as Insulin, Epidermal Growth Factor (EGF), and Forskolin enhance the functional activity of PARD3B by activating the PI3K/AKT, MAPK/ERK, and cAMP/PKA pathways, respectively.
As PARD3B is involved in these pathways, the activation of these pathways enhances the functional activity of PARD3B. Similarly, Retinoic Acid, Isoproterenol, Phorbol 12-Myristate 13-Acetate (PMA), 8-BromocAMP, and Anisomycin activate the retinoic acid receptors (RARs), Beta-adrenergic receptor, Protein Kinase C (PKC), Protein Kinase A (PKA), and the JNK pathway, respectively. Since PARD3B functions within these pathways, their activation enhances the functional activity of PARD3B. In addition, Rho Activator II, Calyculin A, Curcumin, and Dexamethasone enhance the functional activity of PARD3B by activating RhoA, Protein Phosphatase 1 (PP1), the Nrf2 pathway, and glucocorticoid receptors (GRs), respectively. PARD3B is involved in the processes regulated by these pathways and molecules. Therefore, their activation directly or indirectly enhances the functional activity of PARD3B. All these compounds underline the diverse range of biological processes and pathways that are influenced by PARD3B, emphasizing its critical role in maintaining cellular function and integrity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/AKT pathway. Partitioning defective 3 homolog B (PARD3B) is known to function within this pathway as it is involved in cellular polarity and tight junction formation. Activation of the PI3K/AKT pathway enhances PARD3B function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent activator of cyclic AMP (cAMP) leading to the activation of Protein Kinase A (PKA). PARD3B is involved in PKA regulated cell polarity. Activation of PKA enhances the functional activity of PARD3B. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid activates retinoic acid receptors (RARs) which are involved in cell differentiation and development. PARD3B is also involved in these processes. Activation of RARs enhances the functional activity of PARD3B. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol activates the Beta-adrenergic receptor, increasing intracellular cAMP levels, which can activate PKA. PARD3B is involved in PKA regulated cell polarity. Activation of PKA enhances the functional activity of PARD3B. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC), involved in signal transduction processes. PARD3B is involved in PKC regulated cell polarity. Activation of PKC enhances the functional activity of PARD3B. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromo-cAMP, a cell-permeable cAMP analog, activates PKA. PARD3B is involved in PKA regulated cell polarity. Activation of PKA enhances the functional activity of PARD3B. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates the JNK pathway, which is involved in cell polarity and tight junction formation. PARD3B functions within this pathway. Activation of the JNK pathway enhances the functional activity of PARD3B. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A activates Protein Phosphatase 1 (PP1). PP1 is involved in cell polarity and tight junction assembly, processes that PARD3B is also involved in. Activation of PP1 enhances the functional activity of PARD3B. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates the Nrf2 pathway, involved in cellular oxidative stress response. PARD3B functions within this pathway. Activation of the Nrf2 pathway enhances the functional activity of PARD3B. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone activates glucocorticoid receptors (GRs), which are involved in inflammation and immune response. PARD3B functions within these processes. Activation of GRs enhances the functional activity of PARD3B. | ||||||